Selection trials in plant and animal breeding, in incomplete blocks, are described by linear models with random effect parameters associated with treatments with known genetic covariance structure. It is now well known that the information on relatives can improve the analysis and many extensions of this model have been proposed, but no studies have been done on the consequences of this genetical relatedness among treatments for the optimality of block designs. Using a suitable optimality criterion, we show that the knowledge on relatedness may imply that the optimal design is not in the class of designs which are optimal for unrelated treatments. Implications for practical applications are discussed.
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http://dx.doi.org/10.1111/1541-0420.00044 | DOI Listing |
Clin Transl Med
January 2025
Department of Cell Biology, Histology and Embryology, Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria.
The editorial, "Clinical and translational mode of single-cell measurements: An artificial intelligent single-cell," introduces the innovative clinical artificial intelligence single-cell (caiSC) system, which merges AI with single-cell informatics to advance real-time diagnostics, disease monitoring, and treatment prediction. By combining clinical data and multimodal molecular inputs, caiSC facilitates personalized medicine, promising enhanced diagnostic precision and tailored therapeutic approaches. Despite its potential, caiSC lacks comprehensive data coverage across cell types and diseases, presenting challenges in data quality and model robustness.
View Article and Find Full Text PDFFront Genet
December 2024
Department of Animal Science, Faculty of Agriculture, Ferdowsi University of Mashhad, Mashhad, Iran.
Introduction: Identifying genomic regions under selection is the most challenging issue for improving important traits in animals. Few studies have focused on identifying genomic regions under selection in sheep. The aim of this study was to identify selective sweeps and to explore the relationship between these and quantitative trait loci (QTL) in both domestic and wild sheep species using single nucleotide polymorphism markers (SNPs).
View Article and Find Full Text PDFJ Water Health
December 2024
Regional Water and Environmental Sanitation Centre, Department of Civil Engineering, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana.
In 2015, Ghana launched the National Drinking Water Quality Management Framework (NDWQMF) to promote a risk-based approach to water quality through water safety plans (WSPs). This study uses a narrative review to synthesize WSP implementation progress in Ghana, identify gaps in practice, and provide recommendations for enhanced effectiveness and scale-up. Findings show limited uptake: only three of 88 urban water supply systems have adopted WSPs, while in the rural sector, the Community Water and Sanitation Agency has implemented WSPs in 177 of 1,022 small-town systems, and the safe water network in 46 systems.
View Article and Find Full Text PDFFront Neurol
December 2024
Brain Rehabilitation Research Center, Malcom Randall Department of Veterans Affairs Medical Center, North Florida/South Georgia Veterans Health System, Gainesville, FL, United States.
BJOG
December 2024
Department of Women's Cancer, Faculty of Population Health Sciences, Medical School Building, EGA Institute for Women's Health, University College London, London, UK.
Objective: To explore how women appreciated the risks discussed within the consent process for planned caesarean section (CS).
Design: Exploratory qualitative interview study.
Setting: NHS Teaching Hospital in Central London.
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