Variability of B. pertussis genome concerning S1 subunit of pertussis toxin (ptxS1) and pertactin (prn) genes has recently been recognised. Studies clearly showed differences in the DNA patterns and ptxS1 and prn alleles present in B. pertussis strains used for production of pertussis component in the DTP vaccine, in comparison to strains presently isolated from clinical materials. This trend has been observed in highly immunized populations with a long history of pertussis vaccination (The Netherlands, Finland, Poland, USA). Different ptxS1 and prn allele distribution for different countries needs further careful monitoring.
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