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Life-threatening acute respiratory distress syndrome (ARDS) complicates the recovery of patients with burn and inhalation injury. The study by Enkhbaatar and co-workers in this issue of Clinical Science suggests that reducing the early and robust inflammatory cascade may provide patients with protection from developing cardiopulmonary compromise seen early after burn and inhalation injury.
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http://dx.doi.org/10.1042/CS20030275 | DOI Listing |
Curr Res Toxicol
February 2025
ToxStrategies, Durham, NC, United States.
Methyl -butyl ether (MTBE) is a high-octane fuel component that helps gasoline burn cleaner and reduces automobile emissions. In 1999, the International Agency for Research on Cancer (IARC) categorized MTBE as "not classifiable" regarding human carcinogenicity. Since then, additional studies have been published that substantially added to the evidence base to examine the carcinogenic potential of MTBE in humans.
View Article and Find Full Text PDFFront Bioeng Biotechnol
February 2025
Department of Biomedical Engineering and Chemical Engineering, University of Texas at San Antonio, San Antonio, TX, United States.
Background: Inhalation injuries, caused by exposure to extreme heat and chemical irritants, lead to complications with speaking, swallowing, and breathing. This study investigates the effects of thermal injury and endotracheal tube (ETT) placement on the airway microbiome and inflammatory response. A secondary aim is to assess the impact of localized dexamethasone delivery via a drug-eluting ETT to reduce laryngeal scarring.
View Article and Find Full Text PDFJ Trauma Acute Care Surg
March 2025
From the Division of Trauma, Burn and Critical Care Surgery (B.T.S., D.J., S.A.), Harborview Medical Center, University of Washington, Seattle, Washington; Division of Acute Care Surgery (M.A.H.), University of Michigan, Ann Arbor, Michigan; Department of Surgery (L.J.), Emory University, Atlanta, Georgia; and Department of Surgery (L.J.), Uniformed Services University of the Health Sciences, Bethesda, Maryland.
Abstract: There are nearly 700,000 adults and children with burn injuries who seek care in America each year. While most patients with major burn injuries are cared for at American Burn Association-verified burn centers, many of them present to nonburn centers initially or present with combined burns and other injuries. Despite this, burn surgery is no longer mandated by the Accreditation Council for Graduate Medical Education for general surgery residency and is rarely a meaningful component of surgical critical care fellowships.
View Article and Find Full Text PDFBurns
January 2025
Department of Pediatric Surgery, Altona Children's Hospital, Hamburg, Germany; Department of Pediatric Surgery, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Comittee of the German Burn Registry, Germany. Electronic address:
Background: Fluid resuscitation after a burn injury is one of the crucial aspects of acute therapy. The Parkland formula is a quick solution for determining the amount of fluid necessary in a specific situation, although it is not strictly followed or used in current practice. Therefore, we aimed to assess the association between a deviation from the Parkland formula and in-hospital mortality.
View Article and Find Full Text PDFPrehosp Emerg Care
March 2025
Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
The assessment and management of critically injured pregnant trauma patients represents a high-risk, low-frequency event. One in every 12 pregnant patients experience physical trauma during their pregnancy, but only 0.1% experience major trauma with an injury severity score (ISS) greater than fifteen.
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