The morphology and topography of the ciliary ganglia in the midday gerbil and turtle were studied with use of histochemical and histological techniques. The ciliary ganglion of the midday gerbil consisted of two cell agglomerations: the main ganglion and the accessory ganglion. The main ganglion was situated in the orbit and usually closely attached to the nerve for the inferior oblique muscle. The short ciliary nerves arose from the superior end of the main ganglion and reached the orbit. The accessory ciliary ganglion was smaller than the main ganglion. Usually it was attached to short ciliary nerves. The ganglionic neurocytes, 25.97 microm in diameter, were distributed regularly over the entire surface of the main ganglion. They typically had a single clear nucleus. The ciliary ganglion in the turtle formed a characteristic triangular structure on the inferior branch of the oculomotor nerve. The histological examination showed a small number of nerve cells in comparison to the nerve fibres. The neurocytes were placed mainly in the nasal part of ganglion and they had an irregular arrangement. The average diameter of neurons was 23.55 microm. Significant differences in density of ganglionic components in both species were observed. In midday gerbil the cells were densely packed and took up about 80% of a cross-section, while, in the turtle, neurocytes were located mainly in the surface part of ganglion.
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http://dx.doi.org/10.1016/S0940-9602(03)80058-4 | DOI Listing |
Mol Neurobiol
January 2025
The Second School of Clinical Medical College, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
Changes in DNA methylation and subsequent alterations in gene expression have opened a new direction in research related to the pathogenesis of peripheral neuropathic pain (PNP). This study aimed to reveal epigenetic perturbations underlying DNA methylation in the dorsal root ganglion (DRG) of rats with peripheral nerve injury in response to prior exercise and identify potential target genes involved. Male Sprague-Dawley rats were divided into three groups, namely, chronic constriction injury (CCI) of the sciatic nerve, CCI with prior 6-week swimming training (CCI_Ex), and sham operated (Sham).
View Article and Find Full Text PDFProc Biol Sci
January 2025
Department of Zoology, Faculty of Science, Charles University, Prague 128 43, Czech Republic.
African mole-rats (Bathyergidae, Rodentia) are subterranean rodents that live in extensive dark underground tunnel systems and rarely emerge aboveground. They can discriminate between light and dark but show no overt visually driven behaviours except for light-avoidance responses. Their eyes and central visual system are strongly reduced but not degenerated.
View Article and Find Full Text PDFBMC Psychiatry
January 2025
Department of Psychiatry, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-Ku, Yokohama, Kanagawa, 236-0004, Japan.
Background: Paliperidone is a second-generation antipsychotic and the main active metabolite of risperidone, formulated to provide consistent therapeutic effects through an extended-release system, designed to provide consistent therapeutic effects through an extended-release formulation. While commonly used in clinical practice, switching from risperidone to paliperidone, particularly during valproate therapy, can pose challenges due to potential pharmacokinetic interactions that may increase the risk of extrapyramidal symptoms (EPS). Despite clinical observations suggesting these interactions, case reports documenting such adverse effects are scarce.
View Article and Find Full Text PDFJAMA Psychiatry
January 2025
Max Planck Institute of Psychiatry, Munich, Germany.
Importance: As an accessible part of the central nervous system, the retina provides a unique window to study pathophysiological mechanisms of brain disorders in humans. Imaging and electrophysiological studies have revealed retinal alterations across several neuropsychiatric and neurological disorders, but it remains largely unclear which specific cell types and biological mechanisms are involved.
Objective: To determine whether specific retinal cell types are affected by genomic risk for neuropsychiatric and neurological disorders and to explore the mechanisms through which genomic risk converges in these cell types.
Entropy (Basel)
December 2024
Tianjin Key Laboratory of Information Sensing & Intelligent Control, Tianjin University of Technology and Education, Tianjin 300222, China.
Acupuncturing the ST36 acupoint can evoke a responding activity in the spinal dorsal root ganglia and generate spikes. In order to identify the responding mechanism of different acupuncture manipulations, in this paper the spike history of neurons is taken as the starting point and the coupling generalized linear model is adopted to encode the neuronal spiking activity evoked by different acupuncture manipulations. Then, maximum likelihood estimation is used to fit the model parameters and estimate the coupling parameters of stimulus, the self-coupling parameters of the neuron's own spike history and the cross-coupling parameters of other neurons' spike history.
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