In seeking to understand the rise of Justus Liebig's model for research and teaching, three interrelated and overlapping factors intrinsic to his specialty of organic chemistry have not been sufficiently brought into the explanatory field: the discovery of isomers, the novel practice of using "paper tools," and the "Kaliapparat" method of organic analysis. The existence of these three interacting factors, all of which emerged suddenly and essentially simultaneously around 1830, led to an explosive expansion in the new field of organic chemistry. Moreover, they made it a uniquely positioned context within which to create in Germany the practices that eventually were associated with all modern research universities. For comparative purposes, the spread of the new model to France, and more briefly, to the United States is also examined here. The eclectic approach used in this paper places greater emphasis on the contingencies of time, place, and discipline than many earlier studies of this problem have done; it is thus intended to provide a helpful complementary perspective.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1179/amb.2003.50.1.90 | DOI Listing |
Org Lett
January 2025
Key Laboratory of Chemical Biology and Traditional Chinese Medicine (Ministry of Educational of China), Key Laboratory of the Assembly and Application of Organic Functional Molecules of Hunan Province, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, China.
We disclose herein a chiral phosphoric-acid-catalyzed enantioselective addition reaction of alcohols to fluoroalkylated biaryl 1,3-oxoazepines, which furnished a wide range of bridged biaryls bearing a fluoroalkylated quaternary carbon stereocenter on the seven-membered ring in high yields (up to 99%) with excellent enantioselectivities (up to 98% ee). Our method can be used for the modification of several natural products and bioactive molecules. Preliminary studies revealed that the products obtained in this reaction exhibit good in vitro bioactivities against two plant pathogens.
View Article and Find Full Text PDFChem Commun (Camb)
January 2025
Department of Chemistry, Indian Institute of Technology Ropar (IIT Ropar), Rupnagar, Punjab-140 001, India.
Low-energy photoredox catalysis has gained significant attention in developing organic transformations due to its ability to achieve high penetration depth and minimum health risks. Herein, we disclose a red-light ( = 640 nm)-mediated C-3 formylation of indoles utilizing a helical carbenium ion as a photocatalyst and 2,2-dimethoxy-,-dimethylethanamine as a formylating source. These protocols exhibit a broad substrate scope under mild conditions with efficient scalability for the synthesis of C-3 formylated indoles.
View Article and Find Full Text PDFToxicol Res (Camb)
February 2025
Department of chemistry, Emerson University Multan, Multan 60000, Pakistan.
Since the Industrial Revolution, ecological damage, ecosystem disruption, and climate change acceleration have frequently resulted from human advancement at the price of the environment. Due to the rise in illnesses, Industry 6.0 calls for a renewed dedication to sustainability with latest technologies.
View Article and Find Full Text PDFHeliyon
January 2025
Department of Chemistry, Faculty of Basic Sciences, Ilam University, P.O. Box 69315516, Ilam, Iran.
This study highlights an innovative approach to catalysis by utilizing natural asphalt as a support material for developing carbon-based catalysts. By leveraging the principles of green chemistry, the research aims to create recyclable and environmentally friendly heterogeneous catalytic systems. This aligns with the growing demand for greener technologies and the use of biocompatible materials in chemical processes.
View Article and Find Full Text PDFOrganic Synth
January 2024
Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, United States.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!