Objective: To investigate the apoptosis effect induced by D-limonene on BGC-823 gastric cancer cells.
Methods: The expression of p53, bc1-2 in BGC-823 cells and qualitative, quantitative index of cell apoptosis were detected with MTT, electron microscopy, flow cytometry and immunohistochemical method.
Results: D-limonene could induce the formation of apoptotic bodies in a dose- and time-dependent manner. The expression of bcl-2 protein decreased and p53 protein increased in BGC-823 cells treated with D-limonene, compared with the control cells.
Conclusion: D-limonene exerts its cytotoxic effect on BGC-823 gastric cancer cells by inducing apoptosis.
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