AI Article Synopsis
- The study investigated leptin and long form leptin receptors (Ob-R(L)) in the endometrium during the mid-luteal phase of patients with polycystic ovary syndrome (PCOS) compared to normal controls.
- Using techniques like in situ hybridization and immunohistochemistry, researchers found that Ob-R(L) mRNA and protein levels were significantly lower in PCOS patients than in controls, while leptin levels showed no significant differences.
- The decrease in Ob-R(L) expression in PCOS patients may contribute to their lower pregnancy rates during ovulation induction therapies.
Article Abstract
Objective: To study the expression of leptin and long form of leptin receptors (Ob-R(L)) messenger ribonucleic acid (mRNA) and protein in endometrium during mid-luteal phase of patients with polycystic ovary syndrome (PCOS).
Methods: The expression of leptin and Ob-R(L) mRNA in endometrium during mid-luteal phase from 15 normal controls and 14 PCOS related anovulatory patients who underwent ovulation induction therapy were studied by in situ hybridization, and levels of leptin and Ob-R(L) protein were investigated by immunohistochemical methods.
Results: The expression of Ob-R(L) mRNA and protein in endometrial glands of most patients with PCOS were weak or moderate positive, whereas the levels of Ob-R(L) mRNA and protein were moderate or strong positive in those of the controls, there was significant difference between the two groups; leptin mRNA and protein expression in endometrium of patients with PCOS and controls were not significantly different between the groups.
Conclusion: The expression of Ob-R(L) decreased in endometrium of mid-luteal phase in patients with PCOS during induced ovulation, which may be related to low pregnancy rate of patients with PCOS.
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