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State of the art on the development of a recombinant antivenom against Mexican scorpion stings.
Toxicon
March 2025
Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, UNAM, Apartado Postal 510-3, Cuernavaca, Morelos, 62250, Mexico. Electronic address:
Around 2,750 species of scorpions have been recorded worldwide and classified into 21 families and 208 genera. Of these, the family Buthidae stands out as one of the largest, comprising several genera including the genus Centruroides with 102 recorded species. This genus is home to the largest number of species dangerous to humans as described in Mexico, where there are 55 species of the genus Centruroides, of which more than 24 are of medical importance.
View Article and Find Full Text PDFBrown Spider Venom Phospholipases D: From Potent Molecules Involved in Pathogenesis of Brown Spider Bites to Molecular Tools for Studying Ectosomes, Ectocytosis, and Its Applications.
Toxins (Basel)
February 2025
Department of Cell Biology, Federal University of Paraná (UFPR), Curitiba 81530-900, Brazil.
Accidents caused by spiders, commonly known as brown spiders, are frequent in warm and temperate regions worldwide, with a higher prevalence in South America and the southern United States. In the venoms of species clinically associated with accidents, phospholipases D (PLDs) are the most expressed toxins. This classification is based on the toxins' ability to cleave various phospholipids, with a preference for sphingomyelin.
View Article and Find Full Text PDFPediatric scorpion envenoming in Western Mexico.
Salud Publica Mex
April 2024
Pediatrics Emergency Department, Nuevo Hospital Civil de Guadalajara Dr. Juan I. Menchaca. Guadalajara, Jalisco, Mexico..
Clinico-epidemiology of tarantula ( spp.) bites in Sri Lanka.
Clin Toxicol (Phila)
February 2025
Medical Unit, Teaching Hospital, Ratnapura, Sri Lanka.
Introduction: Tarantulas of the genus are medically important arthropods in Sri Lanka and are also found in India. This study aimed to describe the epidemiological and clinical features of tarantula bites in Sri Lanka.
Methods: We conducted a prospective observational study of patients with tarantula bites over 3.
A comparative study of using scorpion antivenom versus scorpion antivenom and prazosin drug for scorpion stings management in Sohag University Hospitals.
BMC Pharmacol Toxicol
February 2025
Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Sohag University, Sohag, Egypt.
Background: Scorpion envenomation is a worldwide problem, especially in tropical and subtropical areas like Egypt. Scorpion envenomation is responsible for the high mortality rate all over the world, which makes much research carried out to see the efficacy of other drugs as supportive treatment in addition to antivenom.
Aim: To see the efficacy of prazosin drug with scorpion antivenom compared to antivenom alone.
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