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Impulsivity behaviors and white matter mediate the relationship between genetic risk for cannabis use disorder and early cannabis use in adolescents.
Addiction
January 2025
Department of Psychiatry, University of Vermont, Burlington, Vermont, USA.
Background And Aim: Cannabis use disorder (CUD) is strongly influenced by genetic factors; however the mechanisms underpinning this association are not well understood. This study investigated whether a polygenic risk score (PRS) based on a genome-wide association study for CUD in adults predicts cannabis use in adolescents and whether the association can be explained by inter-individual variation in structural properties of brain white matter or risk-taking behaviors.
Design And Setting: Longitudinal and cross-sectional analyses using data from the IMAGEN cohort, a European longitudinal study integrating genetic, neuroimaging and behavioral measures.
LFA-1: A potential key player in microglia-mediated neuroprotection against oxygen-glucose deprivation in vitro.
PLoS One
January 2025
Medical Faculty, Department of Neurology, Otto von Guericke University, Magdeburg, Germany.
For the last 38 years, all neuroprotective agents for patients with ischemic stroke have failed in clinical trials. The innate immune system, particularly microglia, is a much-discussed target for neuroprotective agents. Promising results for neuroprotection by inhibition of integrins with drugs such as natalizumab in animal stroke models have not been translated into clinical practice.
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Alzheimers Dement
December 2024
Department of Molecular Imaging & Therapy, Austin Health, Heidelberg, VIC, Australia.
Background: Tau PET is instrumental in tracking the longitudinal progression of Alzheimer's disease (AD). F-MK6240 is a high affinity tracer targeting the 3R/4R paired helical filaments of tau in AD. We aimed to evaluate the early phase of the natural progression of tau accumulation using F-MK6240.
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Alzheimers Dement
December 2024
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, University of Southern California, Marina del Rey, CA, USA.
Background: Normative models (NM) of brain metrics based on large, diverse populations offer novel strategies to detect individual brain abnormalities. To create an age-dependent statistical model of brain microstructure over the human lifespan, we built the largest multi-site NM of white matter (WM) diffusion tensor imaging (DTI) metrics based on 54,591 subjects. We used state-of-the-art tools to adjust for site-dependent effects.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, University of Southern California, Marina del Rey, CA, USA.
Background: High body mass index (BMI) is a risk factor for dementia, and prior diffusion-weighted magnetic resonance (dMRI) work has shown that higher BMI is associated with lower white matter (WM) integrity. The tensor distribution function (TDF) is an advanced dMRI model that is sensitive to the effects of both healthy aging and Alzheimer's disease (Nir et al., 2017; Lawrence et al.
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