AI Article Synopsis
- The study aimed to outline the cytologic characteristics of NK/T-cell lymphoma through an analysis of three cases.
- These lymphomas show a mixture of cell sizes, eccentric nuclei with noticeable nucleoli, and abundant clear to pale cytoplasm, along with often visible mitotic figures and necrotic debris.
- Immunohistochemical markers like CD56, TIA-1, and EBER are valuable tools in aiding the diagnosis of NK/T-cell lymphoma.
Article Abstract
Objective: To describe the diagnostic cytologic features of NK/T-cell lymphoma.
Study Design: The cytologic features of 3 cases of natural killer cell (NK)/T-cell lymphoma were studied and correlated with histology. Immunohistochemistry for CD56, T-cell intracellular antigen (TIA-1) and EBV-encoded small nuclear RNAs (EBER) in situ hybridization was reviewed.
Results: The lymphomas have mixed-sized cells with eccentric, round to ovoid nuclei; 1 or 2 prominent nucleoli; and abundant, clear to pale, eosinophilic cytoplasm. Mitotic figures, necrotic debris and tingible body macrophages are common accompaniments. In fluid, the lymphoma cells appear more shrunken. A clot section of 1 case was positive for CD56, TIA-1 and EBER.
Conclusion: Helpful cytologic features for the diagnosis of NK/T-cell lymphoma are described. Immunohistochemistry for CD56, TIA-1 and EBER in situ hybridization are very helpful adjuncts for the diagnosis.
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| http://dx.doi.org/10.1159/000326574 | DOI Listing |
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