Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/heapro/dag012 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Fifty years with aspirin and platelets.
Br J Pharmacol
January 2023
Department of Pharmacology, Catholic University School of Medicine, Rome, Italy.
In 2021, we reached the 50th anniversary of the publication of Sir John Vane's seminal paper in Nature New Biology describing the experiments supporting his mechanistic hypothesis that inhibition of prostaglandin synthesis might explain the main pharmacological effects of aspirin and aspirin-like drugs, that is, reduction in pain, fever and inflammation. Bengt Samuelsson's subsequent discoveries elucidating the cyclooxygenase pathway of platelet arachidonic acid metabolism motivated my research interest towards measuring platelet thromboxane A biosynthesis as a tool to investigate the clinical pharmacology of cyclooxygenase inhibition by aspirin in health and disease. What followed was a long, winding road of clinical research leading to the characterization of low-dose aspirin as a life-saving antiplatelet drug that still represents the cornerstone of antithrombotic therapy.
View Article and Find Full Text PDFYou can't fool mother nature: new directions in oral contraception.
J Womens Health (Larchmt)
March 2012
Division of Women's Health-Internal Medicine, Mayo Clinic in Arizona, Scottsdale, Arizona 85260, USA.
Data based integration of critical illness and injury patient care from EMS to emergency department to intensive care unit.
Curr Opin Crit Care
August 2009
EMS Performance Improvement Center, Department of Emergency Medicine, University of North Carolina, Chapel Hill, North Carolina, USA.
Purpose Of Review: Describe the challenges and opportunities for an integrated emergency care data system for the delivery and care of critical illness and injury.
Recent Findings: Standardized data comparable across geographies and settings of care has been a critical challenge for emergency care data systems. Emergency medical services (EMS), emergency department (ED), ICU and hospital care are integrated units of service in critical illness and injury care.
Symmetry and structure of RNA and DNA triple helices.
Biopolymers
September 1995
Laboratory of Mathematical Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Despite wide interest in nucleic acid triple helices, there has been no stereochemically satisfactory structure of an RNA triple helix in atomic detail. AN RNA triplex structure has previously been proposed based on fiber diffraction and molecular modeling [S. Arnott and P.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!