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Effectiveness of Self-Help Plus in its digital version in reducing anxiety and post-traumatic symptomatology among nursing home workers during the COVID-19 pandemic: secondary analysis of randomised controlled trial data.
BMJ Ment Health
March 2025
Department of Psychology and Cognitive Science, University of Trento, Trento, Italy
Background: Healthcare workers (HCWs) face substantial daily work-related pressures, leading to frequent reports of depression, anxiety and post-traumatic stress disorder (PTSD) symptoms.
Objective: To compare the effects of Self-Help Plus in its digital version Doing What Matters in Times of Stress (DWM) to an equally structured activity in reducing anxiety and/or PTSD symptoms among HCWs.
Methods: We compared the proportion of participants with moderate-to-severe anxiety (General Anxiety Disorder Scale; GAD-7 ≥10) and/or PTSD symptoms (Impact of Event Scale-Revised (IES-R)) ≥26) between DWM and the alternative activity.
Evaluation of hypoxia pathway genes and serum parameters in new coronavirus pneumonia (COVID-19).
Gene
March 2025
Health Sciences University, Ankara Bilkent City Hospital, Department of Anesthesiology and Reanimation, Ankara, Turkey.
Background: Coronavirus disease-2019 (COVID-19) causes severe hypoxemia. Unlike normal pneumonia, pneumonia due to COVID-19 causes oxygen deprivation without breathing difficulties (i.e.
View Article and Find Full Text PDFTargeting the liquid-liquid phase separation of nucleocapsid broadly inhibits the replication of SARS-CoV-2 strains.
Biochem Biophys Res Commun
March 2025
Nanhu Laboratory, National Center of Biomedical Analysis, Beijing, 100850, China. Electronic address:
The COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to a global public health crisis. The nucleocapsid (N) protein plays a pivotal role in a variety of biological processes in the life cycle of SARS-CoV-2, such as viral assembly. In this study, we investigated the liquid-liquid phase separation (LLPS) capacity of the N protein of seven SARS-CoV-2 strains, including the variants of concern (VOC) and interest (VOI), and its impact on viral replication.
View Article and Find Full Text PDFUnraveling the impact of binary ternary alcohol solutions on the conformation and solvation of the SARS-CoV-2 receptor-binding domain.
Phys Chem Chem Phys
March 2025
Molecular Simulation Laboratory, Department of Chemistry, National Institute of Technology, Rourkela - 769008, India.
The use of alcohol as hand sanitizer to prevent the spread of contamination of SARS-CoV-2 is known. In this work, a series of atomistic molecular dynamics (MD) simulations were carried out with the receptor-binding-domain (RBD) of SARS-CoV-2 in different aqueous binary and ternary mixtures of concentrated ethanol, -propanol (-pr), and iso-propanol (iso-pr) solutions to elucidate the structural alteration of RBD at ambient and elevated temperature and to understand RBD's interactions with the host cellular receptor ACE2. Computation of several structural metrics like RMSD, , and fraction of native contacts along with the construction of a 2D-free energy landscape suggests that among all the water-alcohol(s) solutions, the structural transition of RBD conformation was more pronounced in the water-etoh-iso-pr mixture under ambient conditions which further altered significantly and RBD adopted partially unfolded states at 350 K, as compared to the native form.
View Article and Find Full Text PDFAnalysis of the Influence of the SARS-CoV-2 (COVID-19) Pandemic on the Search for Facial Aesthetic Procedures.
J Craniofac Surg
March 2025
Department of Oral Surgery, Stomatology, Oral Pathology and Oral Radiology, Bauru School Dentistry, University Of São Paulo, Bauru, Brazil.
The SARS-CoV-2 (COVID-19) pandemic caused, in 2020, a serious and urgent health issue worldwide, establishing social distancing rules, which changed daily life in all its aspects. Work relationships and socialization became possible only through virtual networks. As a result, there has been an extreme increase in the exposure of people in general to their own image for many hours a day through cameras and video conferencing applications.
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