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Consensus outcomes between health professionals and parents for oral corticosteroids in treating preschool wheeze: a multi-national survey and nominal group technique study.
Arch Dis Child
January 2025
Department of Child Life and Health, University of Edinburgh Institute for Regeneration and Repair, Edinburgh, UK.
Objective: To obtain priority consensus for outcome measures of oral corticosteroid treatment of preschool wheeze that represent stakeholder groups.
Design: (1) A systematic review to identify a set of outcome measures; (2) an international survey for healthcare professionals (HCPs) and a nominal group meeting with parents; (3) a final consensus nominal group meeting with key HCPs (trial investigators and paediatric emergency medicine clinicians) and the same parent group.
Main Outcome Measures: Consensus priority of treatment outcome measures, outcome minimal clinically important differences (MCIDs) and level of concerns about adverse effects.
A machine learning-based electronic nose for detecting neonatal sepsis: Analysis of volatile organic compound biomarkers in fecal samples.
Clin Chim Acta
January 2025
Department of Physics, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Sekip Utara PO Box BLS 21, Yogyakarta 55281, Indonesia. Electronic address:
Article Synopsis
- - Neonatal sepsis poses a serious threat to newborn health, leading to high rates of illness and death, and emphasizes the need for prompt detection to improve long-term health outcomes.
- - A new, non-invasive technology called cNose, which uses volatile organic compound biomarkers and machine learning algorithms, was developed to quickly diagnose sepsis at the point of care.
- - The cNose system demonstrated high accuracy (90.63%), sensitivity (88.24%), and specificity (93.33%) in identifying sepsis in neonates, showcasing its potential to enhance real-time diagnosis and patient care.
Attitudes and Skills in Basic Life Support after Two Types of Training: Traditional vs. Gamification, of Compulsory Secondary Education Students: A Simulation Study.
Pediatr Rep
July 2024
Faculty of Teacher Training, Universidade de Santiago de Compostela, 27001 Lugo, Spain.
Article Synopsis
- * A comparative analysis involved two groups of secondary students: one receiving traditional BLS training (control group) and the other using a gamified learning method (experimental group).
- * Results showed that the gamified training group demonstrated significantly better attitudes and practical skills related to BLS and AED, suggesting that this method may be as effective or better than classical teaching in preparing students to respond to cardiac emergencies.
Targeted DNA-seq and RNA-seq of Reference Samples with Short-read and Long-read Sequencing.
Sci Data
August 2024
Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, 72079, USA.
Next-generation sequencing (NGS) has revolutionized genomic research by enabling high-throughput, cost-effective genome and transcriptome sequencing accelerating personalized medicine for complex diseases, including cancer. Whole genome/transcriptome sequencing (WGS/WTS) provides comprehensive insights, while targeted sequencing is more cost-effective and sensitive. In comparison to short-read sequencing, which still dominates the field due to high speed and cost-effectiveness, long-read sequencing can overcome alignment limitations and better discriminate similar sequences from alternative transcripts or repetitive regions.
View Article and Find Full Text PDFPerfusion Abnormalities on 24-Hour Perfusion Imaging in Patients With Complete Endovascular Reperfusion.
Stroke
September 2024
Department of Diagnostic and Interventional Neuroradiology (A.M., A.I., S.Z., E.I.P., B.L.S., T.D., A.H., R.W., J.G., J.K.), University of Bern, Switzerland.
Background: Perfusion abnormalities in the infarct and salvaged penumbra have been proposed as a potential reason for poor clinical outcome (modified Rankin Scale score >2) despite complete angiographic reperfusion (Thrombolysis in Cerebral Infarction [TICI3]). In this study, we aimed to identify different microvascular perfusion patterns and their association with clinical outcomes among TICI3 patients.
Methods: University Hospital Bern's stroke registry of all patients between February 2015 and December 2021.
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