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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750303 | PMC |
| http://dx.doi.org/10.1208/pt040107 | DOI Listing |
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Profiling in vitro drug release from subcutaneous implants: a review of current status and potential implications on drug product development.
Biopharm Drug Dispos
May 2006
Department of Pharmaceutics, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298-0533, USA.
This review presents current methods and strategies for studying the release characteristics of drugs from subcutaneous implant dosage forms. Implants are dosage forms that are subcutaneously placed with the aid of surgery or a hypodermic needle, and are designed to release drugs over a prolonged period of time. In most cases, the objective of a release test is to identify sufficiently discriminatory procedures that in turn would provide data to set meaningful specifications.
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