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Development of /Phi as a new dominant selection system for genetic manipulation in .
Microbiol Spectr
January 2025
Laboratory of Molecular Cell Biology, Department of Biochemistry and Center for Excellence in Protein and Enzyme Technology, Faculty of Science, Mahidol University, Bangkok, Thailand.
is a globally distributed pathogenic fungus posing a significant threat to immunocompromised individuals, particularly those with HIV/AIDS. Effective genetic manipulation tools are essential for understanding its biology and developing new therapies. However, current genetic tools, including the variation of versatile selectable markers, are limited.
View Article and Find Full Text PDFDistinct evolutionary trajectories following loss of RNA interference in .
Proc Natl Acad Sci U S A
November 2024
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710.
Article Synopsis
- * Researchers identified clinical isolates with hypermutation due to transposition of a retrotransposon (Cnl1), driven by a mutation in an RNA interference (RNAi) component.
- * A study revealed that while some isolates lose RNAi function without triggering hypermutation, introducing RNAi loss mutations into non-hypermutator strains could induce a hypermutator phenotype, highlighting two possible evolutionary pathways following RNAi loss: either leading to hypermutation or enabling survival without it.
Antimicrobial and antibiofilm activities of Inga cylindrica trypsin inhibitor.
Braz J Biol
September 2024
Universidade Federal de Mato Grosso do Sul, Laboratório de Purificação de Proteínas e Suas Funções Biológicas, Campo Grande, Brasil.
Inga cylindrica, a tropical fruit tree of the Fabaceae family (subfamily Mimosoideae), is native to South America. The seeds from this family are an essential source of trypsin inhibitors, which display promising bioactivity for increasing host defense against pathogens. The aim of the present study was to characterize the antimicrobial and antibiofilm activities of the trypsin inhibitor extracted from I.
View Article and Find Full Text PDFDistinct evolutionary trajectories following loss of RNA interference in .
bioRxiv
October 2024
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.
While increased mutation rates typically have negative consequences in multicellular organisms, hypermutation can be advantageous for microbes adapting to the environment. Previously, we identified two hypermutator clinical isolates that rapidly develop drug resistance due to transposition of a retrotransposon, Cnl1. Cnl1-mediated hypermutation is caused by a nonsense mutation in the gene encoding a novel RNAi component, Znf3, combined with a tremendous transposon burden.
View Article and Find Full Text PDFInfluence of the agrochemical benomyl on Cryptococcus gattii-plant interaction in vitro and in vivo.
Braz J Microbiol
September 2024
Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida Antônio Carlos, 6627, Pampulha, Belo Horizonte, MG, CEP: 31270-901, Brazil.
Cryptococcus gattii, an environmental fungus, is one of the agents of cryptococcosis. The influence of agrochemicals on fungal resistance to antifungals is widely discussed. However, the effects of benomyl (BEN) on fungal interaction with different hosts is still to be understood.
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