The synthesis of several thiazolo[4, 5-d]pyrimidines containing a fluorophenyl moiety substituted at different positions and through different bridges is described. Twenty new compounds were prepared and evaluated for their anticancer activity using the USA-NCI in-vitro screening program. Three compounds were found active and their anticancer activity against 60 human tumor cell lines are described in detail.
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| http://dx.doi.org/10.1002/ardp.200300734 | DOI Listing |
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