AI Article Synopsis
- The SRY gene, located on the Y chromosome, is a key member of the SOX gene family involved in sex determination and development in mammals.
- Sox15, a specific SOX gene, was studied during mouse embryonic development using techniques like whole-mount in situ hybridization and Real Time RT-PCR.
- Findings showed that Sox15 is more actively expressed in male gonads compared to female gonads between 11.5 to 13.5 days post-conception, with the highest expression at 12.5 dpc.
Article Abstract
The mammalian sex determining region on the Y chromosome, SRY, is the founding member of the SOX gene family. SOX genes share a common DNA-binding motif termed the HMG box and have diverse roles in vertebrate embryonic development and tissue differentiation. Sox15 expression was analysed during mouse embryogenesis by whole-mount in situ hybridisation and Real Time RT-PCR. Sox15 was found to be expressed in developing mouse gonads from 11.5 dpc to 13.5 dpc with a peak of expression at 12.5 dpc. Expression was approximately twice as high in the male gonad as in the female gonad.
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| http://dx.doi.org/10.1016/s1567-133x(03)00085-1 | DOI Listing |
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