Aim: In order to look for new active compounds, the structure of (+)-praeruptorin A is modified.
Methods: (+)-Praeruptorin A was isolated from the root of Peucedanum praeruptorum, basic hydrolysis of (+)-praeruptorin A and acyled reactions of hydrolysis product of (+)-praeruptorin A were carried out.
Results: Eighteen compounds were semi-synthesized from (+)-praeruptorin A.
Conclusion: Fourteen compounds (5-18) among them are new compounds. Preliminary bioactivity assay indicated that the new compounds show calcium antagonist activity, but they are not as strong as (+)-praeruptorin A.
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