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ULBP2 promotes progression of head and neck squamous cell carcinoma by modulating MAPK signaling pathway.
J Stomatol Oral Maxillofac Surg
December 2024
Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Oral Disease; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai 200011, China. Electronic address:
Background: UL16-binding protein 2 (ULBP2) is significantly overexpressed in diverse cancers, it may also serve as a potential prognostic factor. Nonetheless, the mechanism of action and functions associated with ULBP2 in head and neck squamous cell carcinoma(HNSCC) are unexplored. This study aims to clarify the role and mechanism of ULBP2 in HNSCC and determine whether this molecule promotes tumor progression through modulation multiple downstream MAPK signaling.
View Article and Find Full Text PDFSynergistic Therapy of Metastatic Breast Cancers by Biomimetic Chemotherapeutic Drug-Gene Nanoparticles.
ACS Appl Mater Interfaces
December 2024
School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, Shanghai 200240, China.
Cancer metastasis is responsible for more than 90% of tumor-related deaths. Especially, metastatic breast cancer (MBC) is a common malignancy with a high mortality among women worldwide. It is urgent to develop effective drugs for the treatment of MBC.
View Article and Find Full Text PDFTertiary lymphoid structures in pancreatic cancer are structurally homologous, share gene expression patterns and B-cell clones with secondary lymphoid organs but show increased T-cell activation.
Cancer Immunol Res
December 2024
University Hospital Cologne, Cologne, NRW, Germany.
Tertiary lymphoid structures (TLS) in cancer are considered ectopic hotspots for immune activation that are similar to lymphoid follicles in secondary lymphoid organs (SLO). This study elucidates shared and TLS/SLO-specific features in pancreatic ductal adenocarcinoma (PDAC). TLS abundance was related to superior survival and T-cell abundance in 110 treatment-naïve PDAC samples, underlining their clinical relevance.
View Article and Find Full Text PDFCardiac metastasis from squamous cell carcinoma of the oral cavity: A rare case report.
Radiol Case Rep
February 2025
Head and Neck Surgery Unit, ENT Department of Geneva University Hospital, Gabrielle-Perret-Gentil 4, 1205 Genève, Switzerland.
A 58-year-old male with squamous cell carcinoma of the floor of mouth underwent surgical planning for tumor resection and floor of mouth reconstruction. Unexpectedly, preoperative cervico-thoracic computed tomography (CT) indicated possible right ventricular intramural thrombosis, prompting initiation of unfractionated heparin. Follow-up echocardiography revealed no thrombus reduction, raising concerns of intracardiac metastasis.
View Article and Find Full Text PDFNatural lung-tropic T9 cells: a sharp weapon for established lung metastases.
J Immunother Cancer
December 2024
Department of Orthopedics, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China
Article Synopsis
- Lung metastasis is a major cause of cancer death, with few effective treatments; T helper 9 (T9) cells show potential in treating tough cases like lung metastases, but more research on their biology is needed.* ! -
- The study involved transferring T1, T9, and T17 cells into different cancer models to compare their effectiveness, using techniques like flow cytometry and RNA sequencing to investigate the reasons behind T9 cells' superior ability to reach the lungs.* ! -
- Results revealed that T9 cells have a stronger ability to target lung metastases due to the CXCR4-CXCL12 pathway, and disabling CXCR4 reduces T9 cells' presence in the lungs, highlighting their
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