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Macular vascular density alteration patterns in paediatric optic neuritis patients with serum MOG antibody positivity detected by optic coherence tomography angiography.
Mult Scler Relat Disord
November 2024
Department of Ophthalmology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China. Electronic address:
Purpose: The retinal microvascular network plays a crucial role in inflammatory injury in paediatric optic neuritis (PON) with serum MOG antibody positivity (MOG + PON). This study compared retinal microvascular densities and structural alterations in MOG + PON eyes with paediatric isolated optic neuritis (PION) eyes and followed up with the final best-corrected visual acuity (BCVA) after 6 months.
Methods: A total of 29 children (52 eyes) with PON, including 15 MOG + PON cases (28 eyes), 6 PION cases (10 eyes), 2 neuromyelitis optica spectrum disorders associated PON(NMOSD-PON) cases (4 eyes), 6 MOG-associated disease (MOGAD) patients without ON-affected eyes (MOG + NPON) cases (10 eyes) and age- and gender-matched healthy controls (HCs) underwent superficial/deep retinal angiography density (SAD/DAD) by optical coherence tomography angiography (OCTA).
A single-center retrospective series of OCT and MRI findings in pediatric MOGAD optic neuritis patients.
Can J Ophthalmol
August 2024
Department of Ophthalmology & Visual Sciences, Washington University in St Louis, St. Louis, MO, USA. Electronic address:
Background: Whether optical computed tomography (OCT) and magnetic resonance imaging (MRI) findings are associated with final visual acuity in children with myelin oligodendrocyte glycoprotein antibody disease (MOGAD) optic neuritis is unclear.
Methods: We retrospectively reviewed the charts of pediatric patients with MOGAD optic neuritis seen at St. Louis Children's Hospital/Barnes Jewish Hospital since 2016.
Clinical features of patients with mutations in genes for nanophthalmos.
Br J Ophthalmol
November 2024
Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, China
Background/aims: To distinguish the clinical feature of nanophthalmos (NNO) caused by mutations in protease serine 56 (), membrane-type frizzled-related protein (), myelin regulatory factor () and transmembrane protein 98 () and to evaluate the association between angle-closure glaucoma (ACG) and NNO.
Methods: Variants in those four genes were identified through exome sequencing/whole genome sequencing data, and bioinformatic analysis was conducted to identify pathogenic/likely pathogenic (P/LP) variants. This observational study comprehensively summarised ophthalmological data of 67 patients with NNO from 63 families.
Non-Invasive High-Resolution Imaging of In Vivo Human Myelinated Axons.
Diagnostics (Basel)
January 2024
Department of Experimental Medicine, Ophthalmology Unit, University of Rome Tor Vergata, 00133 Rome, Italy.
This work aims to reveal the microscopic (2-3 micrometer resolution) appearance of human myelinated nerve fibers in vivo for the first time. We analyzed the myelinated retinal nerve fibers of a male patient without other neurological disorders in a non-invasive way using the transscleral optical phase imaging method with adaptive optics. We also analyzed the fellow eye with non-myelinated nerve fibers and compared the results with traditional ocular imaging methods such as optical coherence tomography.
View Article and Find Full Text PDFMacular Imaging Characteristics in Children with Myelinated Retinal Nerve Fiber and High Myopia Syndrome.
Turk J Ophthalmol
August 2023
Başkent University Faculty of Medicine, Department of Biostatistics, Ankara, Türkiye.
Objectives: To investigate the macular imaging features in patients with unilateral myelinated retinal nerve fiber (MRNF) and high myopia syndrome.
Materials And Methods: Six patients with unilateral MRNF and high myopia syndrome and 13 myopic controls were enrolled in this study. Spectral domain (SD) optical coherence tomography (OCT), SD enhanced depth imaging OCT, and OCT angiography (OCTA) imaging results of MRNF-affected eyes were compared with the fellow eyes and myopic controls.
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