While the standard 200-item version of the Paced Auditory Serial Addition Task (PASAT) is a sensitive neuropsychological instrument, it can be quite aversive to some patients due to its length and progressively increasing difficulty. We present demographically-corrected norms for 50 and 100-item short-form versions in a sample of 560 neurologically normal adults. Age, education, and ethnicity (but not gender) were found to be significant predictors of performance. In a clinical sample of 786 HIV-infected adults, diagnostic accuracy of the 50, 100, and 200-item versions was essentially equivalent (using clinical ratings of a comprehensive neuropsychological battery as the gold standard, overall classification rates of the three PASAT versions were 71%, 74%, and 73%, respectively), with better specificity (89-92%) than sensitivity (46-53%). The 50-item version showed moderate ceiling effects, but the 100-item test did not. In a mixed clinical sample of 40 subjects, the 50-item version was administered more than twice as fast as the 200-item version, and was tolerated better (discomfort rating of 4.0 vs. 5.9 on a 10-point scale, p < .05). We conclude that in many cases the PASAT-50 and PASAT-100 provide equivalent diagnostic accuracy with a significant reduction in administration time and patient discomfort.
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http://dx.doi.org/10.1076/jcen.25.4.571.13876 | DOI Listing |
Mult Scler J Exp Transl Clin
December 2024
Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India.
Background: Cognitive dysfunction in multiple sclerosis (MS) occurs early. Locally adapted neuropsychological data from India in MS is scarce.
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Compr Psychoneuroendocrinol
November 2024
Faculty of Science, Liverpool John Moores University, Liverpool, UK.
Background: The Trier Social Stress Test (TSST) is a widely used laboratory protocol to study acute stress reactivity, a hallmark of which is a meaningful increase in saliva cortisol (>2.5 nmol/L) in most individuals, reflecting hypothalamic-pituitary-adrenal (HPA) axis activation. The Mannheim Multicomponent Stress Test (MMST) has potential as a low staff burden alternative to the TSST, with one study showing statistically significant increases in subjective stress, heart rate and saliva cortisol; however, uncertainty remains about the meaningfulness of these psychobiological responses.
View Article and Find Full Text PDFCaspian J Intern Med
October 2024
Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Background: Cognitive impairment (CI) is one of the main features of multiple sclerosis (MS). Cognitive rehabilitation (CR) programs are crucial for improving cognition and computer-assisted cognitive rehabilitation is considered as an effective method for cognition rehabilitation. To assess the effects of computer-based cognitive rehabilitation program on cognition in patients with multiple sclerosis (MS).
View Article and Find Full Text PDFJ Clin Exp Neuropsychol
November 2024
Department of Psychology, Acibadem University, Istanbul, Türkiye.
Introduction: The extent to which different types of attention are affected in RRMS based on disease duration has not been extensively analyzed. Therefore, the aim of this study was to determine whether MS patients differ compared to healthy individuals in a homogeneous sample of RRMS patients in terms of attention types and from which year of MS attention deficit starts. Another aim of the study was to examine the effect of MS duration and stimulus onset asynchrony on dual task performance.
View Article and Find Full Text PDFBrain Sci
October 2024
Music and Health Science Research Collaboratory, University of Toronto, Toronto, ON M5S 1C5, Canada.
Background: Humans exhibit a remarkable ability to synchronize their actions with external auditory stimuli through a process called auditory-motor or rhythmic entrainment. Positive effects of rhythmic entrainment have been demonstrated in adults with neurological movement disorders, yet the neural substrates supporting the transformation of auditory input into timed rhythmic motor outputs are not fully understood. We aimed to systematically map and synthesize the research on the neural correlates of auditory-motor entrainment and synchronization.
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