In this paper, we propose a standardized set of 480 black-and-white line drawings, half meaningful and half meaningless. Meaningful pictures represent a common object, and were selected from the Snodgrass and Vanderwart set (1980). Meaningless pictures include 120 chimeric objects (made up of two halves of real objects) and 120 nonobjects, that were constructed from the meaningful pictures while controlling for visual complexity. We report the results of two experiments designed to standardize the revisited Snodgrass and Vanderwart set along two important dimensions for picture processing: object manipulability (Experiment 1) and pictorial ambiguity (Experiment 2). The relevance of these dimensions is discussed. Experiment 1 permit us to sort objects into four manipulability categories (i.e., the ease and distinctiveness with which use of the object can be mimed) and to propose a manipulability index. This experiment provides additional evidence for a partial overlap in the dichotomy between man-made objects and living things, on the one hand, and manipulable and unmanipulable objects, on the other hand. In Experiment 2, a pictorial ambiguity index was computed for meaningful and meaningless pictures. The results of this experiment point the distinction between chimeric objects and nonobjects showing that chimeric objects are more complex to process than nonobjects and objects. This standardized set of pictures provides a database and an hopefully useful tool for research in cognitive neuroscience.
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http://dx.doi.org/10.1076/jcen.25.4.521.13873 | DOI Listing |
Transl Neurodegener
March 2025
Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China/Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Background: Intraneuronal accumulation of hyperphosphorylated tau is a hallmark of Alzheimer's disease (AD). Given the significant correlation between tau pathology and memory loss in AD patients, identifying vulnerable brain regions, particularly susceptible neuron types in these regions, will advance our understanding of AD onset and shed light on therapeutic strategies to manage its progression.
Methods: Immunofluorescent staining was employed to identify the brain regions and neuron types vulnerable to tau pathology in AD.
Cytotherapy
December 2024
Department of Hematology, Shanghai Tongji Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address:
Object: Autologous CD19 chimeric antigen receptor T-cell therapy (CAR-T) significantly modifies the natural course of chemorefractory diffuse large B-cell lymphoma (DLBCL). However, 25% to 50% of patients with relapsed/refractory DLBCL still do not achieve remission. Therefore, investigating new molecular prognostic indicators that affect the effectiveness of CAR-T for DLBCL and developing novel combination therapies are crucial.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
August 2024
Department of Neuroscience, Center for Theoretical Neuroscience and Zuckerman Mind, Brain, and Behavior Institute, Columbia University, New York, NY 10027.
When making decisions in a cluttered world, humans and other animals often have to hold multiple items in memory at once-such as the different items on a shopping list. Psychophysical experiments in humans and other animals have shown remembered stimuli can sometimes become confused, with participants reporting chimeric stimuli composed of features from different stimuli. In particular, subjects will often make "swap errors" where they misattribute a feature from one object as belonging to another object.
View Article and Find Full Text PDFFront Pharmacol
June 2024
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, China.
Alzheimer's disease (AD) is one of the most common chronic neurodegenerative diseases. Hyperphosphorylated tau plays an indispensable role in neuronal dysfunction and synaptic damage in AD. Proteolysis-targeting chimeras (PROTACs) are a novel type of chimeric molecule that can degrade target proteins by inducing their polyubiquitination.
View Article and Find Full Text PDFInt J Mol Sci
May 2024
Institute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.
At present, there are a variety of different approaches to the targeted regulation of gene expression. However, most approaches are devoted to the activation of gene transcription, and the methods for gene silencing are much fewer in number. In this review, we describe the main systems used for the targeted suppression of gene expression (including RNA interference (RNAi), chimeric transcription factors, chimeric zinc finger proteins, transcription activator-like effectors (TALEs)-based repressors, optogenetic tools, and CRISPR/Cas-based repressors) and their application in eukaryotes-plants and animals.
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