Objective: The test-retest reliability and the convergent validity of the Fatigue Impact Scale (FIS) were evaluated using secondary data from 54 persons with multiple sclerosis (MS).
Methods: This reliability and validity study used FIS data from before and after two control periods to evaluate test-retest reliability. Convergent validity of the FIS with the Fatigue Severity Scale and with subscales of the SF-36 Health Survey was evaluated using data collected before the first control period.
Results: No significant differences between before and after FIS measurements and intraclass correlation coefficients ranging from .68 to .85 indicate that the FIS has good test-retest reliability except for the physical subscale. The expected moderate correlations between the FIS and several subscales of the SF-36 support its convergent validity. In contrast, the unexpected low correlation between the FIS and Fatigue Severity Scale does not support convergent validity.
Conclusion: The FIS has adequate reliability and validity and is recommended to evaluate the effectiveness of fatigue management interventions such as energy conservation education for persons with MS.
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http://dx.doi.org/10.5014/ajot.57.4.389 | DOI Listing |
JAMA Netw Open
January 2025
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Healthcare Institute, Boston, Massachusetts.
Importance: Uncomplicated urinary tract infection (UTI) is a common indication for outpatient antimicrobial therapy. National guidelines for the management of uncomplicated UTI were published in 2011, but the extent to which they align with current practices, patient diversity, and pathogen biology, all of which have evolved greatly in the time since their publication, is not fully known.
Objective: To reevaluate the effectiveness and adverse event profile for first-line antibiotics, fluoroquinolones, and oral β-lactams for treating uncomplicated UTI in contemporary clinical practice.
Background: Obesity is a global health issue that complicates surgical outcomes, particularly in bariatric/metabolic surgery candidates. Assessing functional capacity is critical for optimizing preoperative planning and postoperative care. The Duke Activity Status Index (DASI) is a simple, self-administered questionnaire that estimates functional capacity based on daily activities.
View Article and Find Full Text PDFEur J Nucl Med Mol Imaging
January 2025
AIDS Imaging Research Section, Division of Clinical Research, NIAID, NIH, Poolesville, MD, USA.
Purpose: Following the initial reports demonstrating the feasibility of immunoPET imaging of simian immunodeficiency virus (SIV) using gp120-targeting monoclonal antibodies in non-human primates, replication efforts of the imaging system in human immunodeficiency virus (HIV)-infected individuals have yielded conflicting results. Herein, we used two anti-gp120 antibodies, 7D3 and ITS103.01LS-F(ab'), to interrogate the reproducibility of gp120-targeting probes for immunoPET imaging of SIV in rhesus macaques.
View Article and Find Full Text PDFSoc Psychiatry Psychiatr Epidemiol
January 2025
Avans University of Applied Sciences, Breda, The Netherlands.
Purpose: Recovery is a key objective in mental health services for people with severe mental illness (SMI). In addition to clinical and functional recovery, personal recovery has gained increasing attention. The CHIME Framework identifies five personal recovery processes-Connectedness, Hope, Identity, Meaning, Empowerment-and is the theoretical foundation for the Brief INSPIRE, a validated Patient-Rated Experience Measure (PREM) to evaluate recovery support.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
January 2025
Beijing University of Chemical Technology, State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing 100029, 100190, Beijing, CHINA.
Oligomerized electron acceptors, featuring molecular weights akin to polymers and well-defined chemical structures, have emerged as promising candidates for organic solar cells (OSCs) due to their consistent batch-to-batch reproducibility and improved thermal stability. In this study, we developed a series of oligomerized electron acceptors incorporating alkynyl linkages via an efficient Sonogashira coupling reaction between alkyne-substituted Y-type precursors and multi-substituted iodobenzenes. This method produced monomeric (S-Alkyne-YF), dimeric (D-Alkyne-YF), and trimeric (T-Alkyne-YF) configurations, enabling systematic control over molecular size and substituent arms.
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