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Innovative Biocompatible Blend Scaffold of Poly(hydroxybutyrate-co-hydroxyvalerate) and Poly(ε-caprolactone) for Bone Tissue Engineering: In Vitro and In Vivo Evaluation.
Polymers (Basel)
October 2024
Centro de Ciências Naturais e Humanas (CCNH), Universidade Federal do ABC (UFABC), São Bernardo do Campo 09606-070, Brazil.
This study evaluated the biocompatibility of dense and porous forms of Poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV), Poly(ε-caprolactone) (PCL), and their 75/25 blend for bone tissue engineering applications. The biomaterials were characterized morphologically using scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR), and the thickness and porosity of the scaffolds were determined. Functional assessments of mesenchymal stem cells (MSCs) included the MTT assay, alkaline phosphatase (ALP) production, and morphological and cytochemical analyses.
View Article and Find Full Text PDF[LPS-induced endothelial cytoskeleton remodeling in human lung vessels and related miRNAs-profiling].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
July 2023
Intensive Care Unit, Cardiocerebral Vascular Disease Hospital, General Hospital of Ningxia Medical University, Yinchuan 750012, China. *Corresponding author, E-mail: mxwei-99@ 163.com.
Objective To investigate the effects of lipopolysaccharide (LPS) on human pulmonary vascular endothelial cells (HPVECs) cytoskeleton and perform biological analysis of the microRNA (miRNA) spectrum. Methods The morphology of HPVECs was observed by microscope, the cytoskeleton by FITC-phalloidin staining, and the expression of VE-cadherin was detected by immunofluorescence cytochemical staining; the tube formation assay was conducted to examine the angiogenesis, along with cell migration test to detect the migration, and JC-1 mitochondrial membrane potential to detect the apoptosis. Illumina small-RNA sequencing was used to identify differentially expressed miRNAs in NC and LPS group.
View Article and Find Full Text PDF[Wnt5a activates JNK to promote the proliferation and autophagy of KGN human granulosa cells].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
November 2022
Key Lab of Ministry of Education for Protection and Utilization of Special Biological Resources in Western China, Department of Microbiology and Molecular Biology, School of Life Sciences, Ningxia University, Yinchuan 750021, China. *Corresponding author, E-mail:
Objective To investigate the effect of Wnt5a on autophagy in KGN human granulosa cells. Methods KGN human granulosa cells were treated with DMSO (control group), recombinant Wnt5a protein (rWnt5a), Wnt5a inhibitor IWP2 or BOX5, separately. The expression level of Wnt5a protein was detected by Western blot.
View Article and Find Full Text PDF[Wnt5a regulates SiO-induced ferroptosis in mouse alveolar macrophages by positive feedback].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
August 2022
Clinical Laboratory Diagnosis Center, People's Hospital of Ningxia Hui Autonomous Region, Yinchuan 750001, China. *Corresponding author, E-mail:
Objective To investigate the potential role of Wnt5a signaling in SiO-induced ferroptosis in mouse alveolar macrophages. Methods C57BL/6 mice were treated by intratracheal instillation of crystalline silica (SiO) or saline, and plasma and bronchial alveolar lavage fluid (BALF) were harvested at 24 hours post injury. Immunofluorescence cytochemical staining was used to detect the expression of Wnt5a, p65 (NF-κB p65) and Toll-like receptor 4 (TLR4) in alveolar macrophages.
View Article and Find Full Text PDFA Senolytic-Eluting Coronary Stent for the Prevention of In-Stent Restenosis.
ACS Biomater Sci Eng
May 2022
School of Chemical and Biological Engineering, Seoul National University, Seoul 08826, Republic of Korea.
The vast majority of drug-eluting stents (DES) elute either sirolimus or one of its analogues. While limus drugs stymie vascular smooth muscle cell (VSMC) proliferation to prevent in-stent restenosis, their antiproliferative nature is indiscriminate and limits healing of the endothelium in stented vessels, increasing the risk of late-stent thrombosis. Oxidative stress, which is associated with vascular injury from stent implantation, can induce VSMCs to undergo senescence, and senescent VSMCs can produce pro-inflammatory cytokines capable of inducing proliferation of neighboring nonsenescent VSMCs.
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