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A new sympathetic understanding of exercise blood flow regulation in heart failure with preserved ejection fraction.
J Physiol
October 2024
Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, TX, USA.
α-Adrenergic regulation of blood flow in HFpEF: too much and not enough.
J Physiol
July 2024
Institute for Exercise and Environmental Medicine, University of Texas Southwestern Medical Center & Texas Health, Presbyterian Hospital Dallas, Dallas, Texas, USA.
α-Adrenergic regulation of skeletal muscle blood flow during exercise in patients with heart failure with preserved ejection fraction.
J Physiol
July 2024
Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT, USA.
Heart failure with preserved ejection fraction (HFpEF) has been characterized by lower blood flow to exercising limbs and lower peak oxygen utilization ( ), possibly associated with disease-related changes in sympathetic (α-adrenergic) signaling. Thus, in seven patients with HFpEF (70 ± 6 years, 3 female/4 male) and seven controls (CON) (66 ± 3 years, 3 female/4 male), we examined changes (%Δ) in leg blood flow (LBF, Doppler ultrasound) and leg to intra-arterial infusion of phentolamine (PHEN, α-adrenergic antagonist) or phenylephrine (PE, α-adrenergic agonist) at rest and during single-leg knee-extension exercise (0, 5 and 10 W). At rest, the PHEN-induced increase in LBF was not different between groups, but PE-induced reductions in LBF were lower in HFpEF (-16% ± 4% vs.
View Article and Find Full Text PDFElevated sympathetic-mediated vasoconstriction at rest but intact functional sympatholysis during exercise in heart failure with reduced ejection fraction.
Am J Physiol Heart Circ Physiol
July 2024
College of Kinesiology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Patients with heart failure with reduced ejection fraction (HFrEF) have exaggerated sympathoexcitation and impaired peripheral vascular conductance. Evidence demonstrating consequent impaired functional sympatholysis is limited in HFrEF. This study aimed to determine the magnitude of reduced limb vascular conductance during sympathoexcitation and whether functional sympatholysis would abolish such reductions in HFrEF.
View Article and Find Full Text PDFCerebral sympatholysis: experiments on in vivo cerebrovascular regulation and ex vivo cerebral vasomotor control.
Am J Physiol Heart Circ Physiol
May 2024
Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Whether cerebral sympathetic-mediated vasomotor control can be modulated by local brain activity remains unknown. This study tested the hypothesis that the application or removal of a cognitive task during a cold pressor test (CPT) would attenuate and restore decreases in cerebrovascular conductance (CVC), respectively. Middle cerebral artery blood velocity (transcranial Doppler) and mean arterial pressure (finger photoplethysmography) were examined in healthy adults ( = 16; 8 females and 8 males) who completed a control CPT, followed by a CPT coupled with a cognitive task administered either ) 30 s after the onset of the CPT and for the duration of the CPT or ) at the onset of the CPT and terminated 30 s before the end of the CPT (condition order was counterbalanced).
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