AI Article Synopsis
- The study aimed to identify a specific haplotype in the PRKCZ gene linked to type 2 diabetes in the Han population of North China through a case-control study and genetic analysis.
- Researchers genotyped single nucleotide polymorphisms (SNPs) from the PRKCZ gene in 173 diabetes patients and 152 healthy individuals to analyze their genetic variations.
- The findings revealed several SNPs associated with type 2 diabetes, showing notable differences in haplotype frequencies between the patient and control groups, suggesting that these genetic variations may contribute to the disease's susceptibility.
Article Abstract
Objective: To search for the disease-associated haplotype in the PRKCZ gene, a susceptibility gene for type 2 diabetes in Han population of North China, by case-control study and linkage disequilibrium (LD) analysis using single nucleotide polymorphisms (SNPs).
Methods: SNPs located in the PRKCZ gene were chosen from public SNP domain by bioinformatic methods and single base extension (SBE) method was used to genotype the loci in 173 sporadic type 2 diabetes patients and 152 normal individuals to perform case-control study and LD analysis. Haplotype block were constructed in these populations.
Results: Several SNPs in the PRKCZ gene were found to be associated with the disease. The SNPs formed different haplotype block pattern in case and control groups. The frequencies of the haplotypes formed by 5 SNPs were statistically different between the two groups.
Conclusion: The haplotype formed by 5 SNPs in the PRKCZ gene may be associated with type 2 diabetes in Han population of China, which is confirmed from statistics to be a susceptibility gene for the disease.
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