AI Article Synopsis
- P300 is an event-related potential activated by an oddball paradigm, with notable differences in latency and amplitude observed in neuropsychiatric diseases compared to healthy individuals.
- Multiple studies aim to uncover the brain regions responsible for generating the P300 component due to its clinical relevance.
- In this study, 15 healthy participants underwent fMRI while exposed to an auditory oddball task, revealing significant activation in areas such as the inferior and middle frontal, superior temporal, lower parietal cortex, insula, and anterior cingulate, symmetrically across both hemispheres.
Article Abstract
P300 is an event-related potential that is elicited by an oddball paradigm. In several neuropsychiatric diseases, differences in latencies and amplitude compared to healthy subjects have been reported. Because of its clinical significance, several investigations have tried to elucidate the intracranial origins of the P300 component. In the present study we could demonstrate a network of P300 generators. Investigated were 15 healthy subjects with an acoustical oddball paradigm within a fMRI block design, which enabled us to exclude attention or acoustical processing effects. The inferior and middle frontal, superior temporal, lower parietal cortex, the insula and the anterior cingulum were significantly activated symmetrical in both hemispheres.
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| http://dx.doi.org/10.1007/s00406-003-0419-4 | DOI Listing |
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