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[Prevalence and genetic characteristics of infections among HIV-positive individuals in Jiangxi Province].
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi
July 2024
Nanchang Municipal Center for Disease Control and Prevention, Base of National Key Laboratory for the Prevention and Control of Infectious Diseases, Nanchang, Jiangxi 330038, China.
Objective: To investigate the prevalence of infection and the distribution of parasite species and genotypes among HIV-positive individuals in Jiangxi Province.
Methods: HIV-positive individuals' sociodemographic and clinical data were collected from three AIDS designated hospitals in Jiangxi Province from January 2022 to March 2023. Subjects' stool samples were collected, and genomic DNA was extracted from stool samples.
Causal Inference With Observational Data and Unobserved Confounding Variables.
Ecol Lett
January 2025
Department of Ecology and Evolutionary Biology, University of Colorado Boulder, Boulder, Colorado, USA.
Experiments have long been the gold standard for causal inference in Ecology. As Ecology tackles progressively larger problems, however, we are moving beyond the scales at which randomised controlled experiments are feasible. To answer causal questions at scale, we need to also use observational data -something Ecologists tend to view with great scepticism.
View Article and Find Full Text PDFMachine learning for estimating and comparing clinical rules for treating diarrheal illness with antibiotics.
medRxiv
January 2025
Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Georgia, USA.
Acute diarrheal disease is one of the leading causes of death in children under age 5, disproportionately impacting children in low-resource settings. Many of these cases are caused by bacteria and therefore could respond to antibiotic treatment; however, the benefits of widely prescribing antibiotics must be weighed against the risks for the emergence of microbial resistance. These challenges present the opportunity for developing individualized treatment guidelines for diarrheal disease.
View Article and Find Full Text PDFQuantifying intratumoral biomarker heterogeneity in tubo-ovarian high-grade serous carcinoma to optimize clinical translation.
Sci Rep
January 2025
Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB, T2N 2T9, Canada.
Intratumoral heterogeneity (ITH) is spatial, phenotypic, or molecular differences within the same tumor that have important implications for accurate tumor classification and assessment of predictive biomarkers. The Canadian Ovarian Experimental Unified Resource (COEUR) has created a cohort of 437 FFPE tissue specimens from 108 tubo-ovarian high-grade serous carcinoma (HGSC) patients to quantify ITH across the anatomical sites and between primary and recurrence. We quantified the ITH of six clinically used immunohistochemical diagnostic and prognostic biomarkers (WT1, p53, p16, PR, CD8, and Ki67).
View Article and Find Full Text PDFFrequency of in dogs from the municipality of Veracruz, Mexico.
Vet Res Forum
December 2024
Department of Veterinary Microbiology, Faculty of Veterinary Medicine and Animal Science, University of Veracruz, Veracruz, Mexico.
Infectious canine cyclic thrombocytopenia or canine anaplasmosis is an infectious disease caused by . In Mexico, cases of human infection have been reported. The present cross-sectional study aimed to determine the frequency of infection in the municipality of Veracruz, Mexico, by nested polymerase chain reaction method.
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