AI Article Synopsis
- The 2',5'-oligoadenylate (2-5A) is a key player that inhibits protein translation in vertebrate cells by activating RNase L, an endoribonuclease.
- This 2-5A mechanism is crucial in the body's defense against viral infections through interferon pathways.
- The study discusses the creation of modified 2-5A derivatives, their engagement with RNase L, and their stability in biological settings.
Article Abstract
The unique 2',5'-oligoadenylate (2-5A) acts as a potent inhibitor of translation in vertebrate cells through the activation of a constituent latent 2-5A-dependent endoribonuclease (RNase L). This 2-5A system plays a major role in the interferon natural defense mechanism against viral infection. We report the syntheses of base-modified adenosine-substituted 2-5A derivatives, their interaction with recombinant human RNase L and their biological stability.
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