AI Article Synopsis
- The study aimed to explore how specific genetic variations (VNTR and 5-HTTLPR) in the serotonin transporter gene relate to schizophrenia in the Han Chinese population.
- Researchers analyzed 314 samples of families with a schizophrenic member using a transmission/disequilibrium test to assess these genetic variations.
- Findings showed no significant preference for any genetic allele linked to schizophrenia, indicating that the serotonin transporter gene may not play a major role in increasing susceptibility to the disorder in this population.
Article Abstract
Objective: To investigate the relationship between two polymorphisms (Intronic VNTR and 5-HTTLPR) of the serotonin transporter gene and schizophrenia.
Methods: A set of 314 schizophrenic trio samples collected from Shanghai, Xi'an and Jilin regions of China independently was subjected to analysis of the polymorphisms by transmission/disequilibrium test(TDT).
Results: No significantly preferential transmission of any allele was detected from both polymorphisms investigated.
Conclusion: The results suggest that the serotonin transporter gene is unlikely to have a major contribution to susceptibility to schizophrenia in Han Chinese population.
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