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Fluorescence molecular imaging-guided photodynamic therapy for early breast cancer in the prone position: feasibility evaluation with Monte Carlo simulations.
Photodiagnosis Photodyn Ther
January 2025
Maebashi-Institute of Technology, Systems Life Engineering, Gunma, 371-0816 Japan. Electronic address:
Introduction: The successful diagnosis and treatment of early-stage breast cancer enhances the quality of life of patients. As a promising alternative to recently developed magnetic resonance imaging-guided radiotherapy, we proposed fluorescence molecular imaging-guided photodynamic therapy (FMI-guided PDT), which requires no expensive equipment. In the FMI simulations, ICG-C11 which has emission peaks at near-infrared wavelengths was used as the FMI agent.
View Article and Find Full Text PDFIntratumoral delivery of Mitomycin C using bio-responsive Gellan Gum Nanogel: In-vitro evaluation and enhanced chemotherapeutic efficacy.
Int J Biol Macromol
January 2025
Division of Pharmaceutics and Pharmacokinetics, CSIR-Central Drug Research Institute, Lucknow 226031, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address:
Intratumoral drug delivery systems hold immense promise in overcoming the limitations of conventional IV chemotherapy, particularly in enhancing therapeutic efficacy and minimizing systemic side effects. In this study, we introduce a novel redox-responsive intratumoral nanogel system that combines the biocompatibility of natural polysaccharides with the tailored properties of synthetic polymers. The nanogel features a unique cross-linked architecture incorporating redox-sensitive segments, designed to leverage the elevated glutathione levels in the tumor microenvironment for controlled drug release.
View Article and Find Full Text PDFNew molecular hybrids integrated with quinoxaline and pyrazole structural motifs: VGFR2 inhibitors and apoptosis inducers.
Bioorg Chem
January 2025
Department of Chemistry, Faculty of Science, Al-Azhar University, Cairo 11754 Egypt.
The vascular endothelial growth factor receptor is essential for the angiogenesis of cancer. Tumor propagation was effectively suppressed by inhibiting VEGFR-2 activity. As a result, the target quinoxaline-pyrazole hybrids were created in a way that closely resembled the structural characteristics of VEGFR-2 inhibitors.
View Article and Find Full Text PDFFast optimization of the emission reduction pathways of major air pollutants in China: From the perspective of different decision preferences.
Environ Int
January 2025
Institute of Atmospheric Environment, Chinese Academy of Environmental Planning, Beijing 100012, China; Center of Synergistic Control for Reducing Pollution and Carbon Emissions, Chinese Academy of Environmental Planning, Beijing 100012, China. Electronic address:
To address the concern of optimization problem of China's PM control and the limitation of computational efficiencies for traditional air quality models, we developed an integrated analysis framework to efficiently establish the identification and cost-benefit assessment of PM control pathways in China by constructing a rapid PM exposure response method based on the high-order decoupled direct method (HDDM) and coupling the sequential least square algorithm (SLSQP) and health impact assessment model. Six emission reduction scenarios with varying decision preferences were analyzed. Our study provides a methodological approach for the rapid optimization of emission pathways of major air pollutants in China with flexible options in terms of objectives and constraints, fully considering the diverse differences in environmental, health, and economic impacts among different pollution sources simultaneously.
View Article and Find Full Text PDFJoint image reconstruction and segmentation of real-time cardiac MRI in free-breathing using a model based on disentangled representation learning.
J Cardiovasc Magn Reson
January 2025
Department of Diagnostic and Interventional Radiology, University Hospital Würzburg, Würzburg, Germany.
Purpose: To investigate image quality and agreement of derived cardiac function parameters in a novel joint image reconstruction and segmentation approach based on disentangled representation learning, enabling real-time cardiac cine imaging during free-breathing.
Methods: A multi-tasking neural network architecture, incorporating disentangled representation learning, was trained using simulated examinations based on data from a public repository along with MR scans specifically acquired for model development. An exploratory feasibility study evaluated the method on undersampled real-time acquisitions using an in-house developed spiral bSSFP pulse sequence in eight healthy participants and five patients with intermittent atrial fibrillation.
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