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Conserved multisensory integration of social cues in the thalamus.
iScience
January 2025
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
The recognition of conspecifics, animals of the same species, and keeping track of changes in the social environment is essential to all animals. While molecules, circuits, and brain regions that control social behaviors across species are studied in-depth, the neural mechanisms that enable the recognition of social cues are largely obscure. Recent evidence suggests that social cues across sensory modalities converge in a thalamic area conserved across vertebrates.
View Article and Find Full Text PDFTendon evaluation with ultrashort Echo Time (UTE) MRI: A Systematic Review.
Front Musculoskelet Disord
March 2024
Department of Radiology, University of California, San Diego, San Diego, CA, United States.
Tendon disease ranks among the leading reasons patients consult their general practitioners, comprising approximately one-third of musculoskeletal appointments. Magnetic resonance imaging (MRI) is regarded as the gold standard for assessing tendons. Due to their short transverse relaxation time (T2), Tendons show up as a signal void in conventional MRI scans, which employ sequences with echo times (TEs) around several milliseconds.
View Article and Find Full Text PDFDevelopment of Effective Connectome from Infancy to Adolescence.
Med Image Comput Comput Assist Interv
October 2024
Department of Radiology and Biomedical Research Imaging Center (BRIC), University of North Carolina at Chapel Hill, Chapel Hill, USA.
Delineating the normative developmental profile of functional connectome is important for both standardized assessment of individual growth and early detection of diseases. However, functional connectome has been mostly studied using functional connectivity (FC), where undirected connectivity strengths are estimated from statistical correlation of resting-state functional MRI (rs-fMRI) signals. To address this limitation, we applied regression dynamic causal modeling (rDCM) to delineate the developmental trajectories of effective connectivity (EC), the directed causal influence among neuronal populations, in whole-brain networks from infancy to adolescence (0-22 years old) based on high-quality rs-fMRI data from Baby Connectome Project (BCP) and Human Connectome Project Development (HCP-D).
View Article and Find Full Text PDFLate-Stage Minimal Labeling of Peptides and Proteins for Real-Time Imaging of Cellular Trafficking.
ACS Cent Sci
January 2025
Centre for Inflammation Research, The University of Edinburgh, EH16 4UU Edinburgh, U.K.
The cellular uptake routes of peptides and proteins are complex and diverse, often handicapping therapeutic success. Understanding their mechanisms of internalization requires chemical derivatization with approaches that are compatible with wash-free and real-time imaging. In this work, we developed a new late-stage labeling strategy for unprotected peptides and proteins, which retains their biological activity while enabling live-cell imaging of uptake and intracellular trafficking.
View Article and Find Full Text PDFReview of directional leads, stimulation patterns and programming strategies for deep brain stimulation.
Cogn Neurodyn
December 2025
Academy of Medical Engineering and Translational Medicine of Tianjin University, Tianjin, 300072 China.
Deep brain stimulation (DBS) is a well-established treatment for both neurological and psychiatric disorders. Directional DBS has the potential to minimize stimulation-induced side effects and maximize clinical benefits. Many new directional leads, stimulation patterns and programming strategies have been developed in recent years.
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