AI Article Synopsis
- The study examined the impact of the 3111T/C CLOCK gene polymorphism on sleep disorders in 620 patients with major depressive disorder (MDD) and bipolar disorder (BP).
- Homozygotes for the C variant showed a significantly higher occurrence of various types of insomnia and a trend of reduced sleep need in bipolar disorder patients.
- The findings suggest that the CLOCK gene polymorphism may play a role in sleep disruptions associated with MDD and BP, although other demographic and clinical factors were not linked to these polymorphisms.
Article Abstract
We investigated the possible effect of the 3111T/C CLOCK gene polymorphism on sleep disorders in a sample of 620 patients affected by major depressive disorder (MDD) and bipolar disorder (BP). We detected a significantly higher recurrence of initial (P = 0.0001), middle (P = 0.0009), and early (P = 0.0008) insomnia in homozygotes for the C variant and a similar trend concerning decreased need of sleep in BP (P = 0.0074). Other demographic and clinical features were found not related with CLOCK polymorphisms. This preliminary observation leads to hypothesize a possible involvement of the CLOCK gene polymorphism in the sleep disregulations in MDD and BP.
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| http://dx.doi.org/10.1002/ajmg.b.20053 | DOI Listing |
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