Systematic reviews provide the best evidence on the effectiveness of healthcare interventions including quality improvement strategies. The methods of systematic review of individual patient randomised trials of healthcare interventions are well developed. We discuss methodological and practice issues that need to be considered when undertaking systematic reviews of quality improvement strategies including developing a review protocol, identifying and screening evidence sources, quality assessment and data abstraction, analytical methods, reporting systematic reviews, and appraising systematic reviews. This paper builds on our experiences within the Cochrane Effective Practice and Organisation of Care (EPOC) review group.
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http://dx.doi.org/10.1136/qhc.12.4.298 | DOI Listing |
J Diabetes
January 2025
Department of Clinical Epidemiology and Biostatistics, Peking University People's Hospital, Beijing, China.
Understanding is limited regarding strategies for addressing missing value when developing and validating models to predict cardiovascular disease (CVD) in type 2 diabetes mellitus (T2DM). This study aimed to investigate the presence of and approaches to missing data in these prediction models. The MEDLINE electronic database was systematically searched for English-language studies from inception to June 30, 2024.
View Article and Find Full Text PDFEur J Trauma Emerg Surg
January 2025
Department of Orthopaedic, Clinic of Wels-Grieskirchen, 4600, Wels, Austria.
Introduction: The minimal clinically important difference (MCID), patient-acceptable symptom state (PASS), and substantial clinical benefit (SCB) are designed to prioritise clinically significant outcomes that demonstrate true clinical benefit rather than relying solely on statistical significance. These instruments aid clinicians in understanding the patient's perspective, allowing healthcare professionals to set treatment goals that align with patients' desires and expectations. This systematic review analysed tools to estimate the clinical relevance of the most commonly used PROMs to assess patients following surgical knee ligament reconstruction.
View Article and Find Full Text PDFAAPS J
January 2025
Certara UK Limited, Level 2, Acero, 1 Concourse Way, Sheffield, S1 2BJ, UK.
Bile salts are biosurfactants released into the intestinal lumen which play an important role in the solubilisation of fats and certain drugs. Their concentrations vary along the gastrointestinal tract (GIT). This is significant for implementation in physiologically based pharmacokinetic (PBPK) modelling to mechanistically capture drug absorption.
View Article and Find Full Text PDFNeurosurg Rev
January 2025
Department of Neurological Surgery, Oregon Health & Science University, Portland, OR, USA.
Deep brain stimulation (DBS) is a valuable treatment for Parkinson's disease (PD), but postoperative delirium (POD) is a common complication. Understanding the risk factors for POD is crucial for optimizing patient selection and developing preventative measures. This systematic review and meta-analysis aims to identify predictors of POD in PD patients undergoing DBS surgery.
View Article and Find Full Text PDFJ Gen Intern Med
January 2025
Department of Medicine, University of Calgary, Calgary, Alberta, Canada.
Background: Early physician follow-up after hospital discharge is commonly recommended, though whether it mitigates adverse events is unclear. We conducted a systematic review and meta-analysis to examine the association between physician follow-up within 30 days of hospital discharge and risk of hospital readmission, emergency department (ED) visits, or mortality in medical patients.
Methods: MEDLINE, EMBASE, and CINAHL electronic databases were searched from inception to April 2023.
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