Objective: To assess the impact of supplementing newborn infants with vitamin A on mortality at age 6 months.
Design: Community based, randomised, double blind, placebo controlled trial.
Setting: Two rural districts of Tamil Nadu, southern India.
Participants: 11 619 newborn infants allocated 24 000 IU oral vitamin A or placebo on days 1 and 2 after delivery.
Main Outcome Measure: Primary outcome measure was mortality at age 6 months.
Results: Infants in the vitamin A group had a 22% reduction in total mortality (95% confidence interval 4% to 37%) compared with those in the placebo group. Vitamin A had an impact on mortality between two weeks and three months after treatment, with no additional impact after three months.
Conclusion: Supplementing newborn infants with vitamin A can significantly reduce early infant mortality.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC167159 | PMC |
| http://dx.doi.org/10.1136/bmj.327.7409.254 | DOI Listing |
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