The epithelial-specific Ets factors occupy a unique position in defining epithelial proliferation, differentiation and carcinogenesis.

Anticancer Res

Laboratory of Cancer Genomics, Hollings Cancer Center, Medical University of South Carolina, 86 Jonathan Lucas St. Rm 327, Charleston, SC 29425, USA.

Published: August 2003

The Ets family of transcription factors regulates many biological processes. Within the Ets family are a subset of proteins that have epithelial restricted expression patterns, both in tissues and cell lines. These Epithelial-specific Ets (Ese) factors, cluster into two groups based on the sequence of the Ets DNA binding domain: (i) Ese1, Ese2 and Ese3, and (ii) the more divergent, Pdef. Gene targeting and cell culture studies have demonstrated that Ese factors are important for cellular differentiation. Furthermore, the ability of Ese factors to regulate expression of genes that are markers of differentiation supports this model. Significantly, the expression profile of these Ese factors is altered in epithelial cancers relative to the respective normal tissues. It is likely that this variation in expression affects downstream target genes important for carcinogenesis such as oncogenes and tumor suppressor genes. Understanding the role of these Ese factors in normal cellular differentiation may elucidate specific mechanisms by which cancer cells can become undifferentiated.

Download full-text PDF

Source

Publication Analysis

Top Keywords

ese factors
20
epithelial-specific ets
8
ets family
8
cellular differentiation
8
factors
7
ese
5
ets factors
4
factors occupy
4
occupy unique
4
unique position
4

Similar Publications

Unveiling the interplay between knowledge, self-efficacy, and pro-environmental behavior about climate change in a sample of rural community-dwelling older adults: A national correlational study.

Geriatr Nurs

January 2025

Psychiatric and Mental Health Specialty, Nursing Department, College of Health and Sport Sciences, University of Bahrain, Manama, Bahrain; Psychiatric and Mental Health Nursing Department, Faculty of Nursing, Alexandria University, Alexandria, Egypt. Electronic address:

Background: Climate change is a global health concern that affects all of humanity, but it disproportionately impacts older adults, particularly those living in rural communities. Older adults lack the ability to actively engage in pro-environmental actions aimed at adapting to and mitigating the harmful effects of climate change.

Aim: To investigate the relationship between knowledge, self-efficacy, and pro-environmental behavior regarding climate change, as well as to identify the factors that predict pro-environmental behavior in a sample of rural community-dwelling older adults.

View Article and Find Full Text PDF

Background: LIN28, a highly conserved RNA-binding protein, regulate a wide variety of post-transcriptional cellular processes. The current study aimed to identify genetic variants of five single nucleotide polymorphisms (SNPs) in the LIN28B gene (rs221634, rs22163, rs314276, rs9404590, and rs12194974) and their association with Breast cancer.

Method: 220 patients and 230 controls were genotyped by the RFLP assay for Lin28B gene variants.

View Article and Find Full Text PDF

[Not Available].

Vertex

January 2025

Médico neurólogo. Especialista en Enfermedades cerebrovasculares. Servicio de Neurología, Complejo Médico Churruca Visca, Buenos Aires, Argentina. .

Introducción: El accidente cerebrovascular es un factor de riesgo para el trastorno neurocognitivo. Se ha reportado la presencia de trastorno neurocognitivo post accidente cerebrovascular en el 20 al 80 % de los casos, según diferentes series. Asimismo, se reportan síntomas neuropsiquiátricos luego de ese evento, siendo lo más frecuente la depresión.

View Article and Find Full Text PDF

Large-scale commercial-grade volatile fatty acids production from sewage sludge and food waste: A holistic environmental assessment.

Environ Sci Ecotechnol

January 2025

CRETUS, Department of Chemical Engineering. Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain.

The valorization of sewage sludge and food waste to produce energy and fertilizers is a well-stablished strategy within the circular economy. Despite the success of numerous laboratory-scale experiments in converting waste into high-value products such as volatile fatty acids (VFAs), large-scale implementation remains limited due to various technical and environmental challenges. Here, we evaluate the environmental performance of a hypothetical large-scale VFAs biorefinery located in Galicia, Spain, which integrates fermentation and purification processes to obtain commercial-grade VFAs based on primary data from pilot plant operations.

View Article and Find Full Text PDF

Background: Routine epidemiological data are essential for monitoring the effectiveness of preventive chemotherapy (PC), optimizing resource allocation, and addressing the evolving needs in the elimination of soil-transmitted helminthiasis (STH). This study assesses the prevalence, intensity, and associated risk factors of STH following five rounds of albendazole-based PC in three implementation units (IUs) in Ondo State, Nigeria.

Methodology: Fresh stool samples were collected from 2,093 children aged 5-14 years across 45 systematically selected schools in three IUs: Ese-Odo, Irele, and Ile-Oluji.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!