AI Article Synopsis
- - The case involves a female patient who experienced a sudden skin eruption characterized by purple spots and blisters primarily on her lower legs.
- - Skin biopsies revealed microvascular blockages with blood clots but showed no signs of inflammation in the skin's dermal layer.
- - The study identifies elevated levels of homocysteine and transient antiphospholipid antibodies as potential contributors to a clotting disorder that may have triggered the skin lesions.
Article Abstract
We describe a female patient with an acute purpuric and bullous eruption mainly affecting the lower aspect of the legs. Skin biopsy specimens demonstrated microvascular occlusions with fibrin thrombi but no dermal inflammation. Intermediate hyperhomocysteinemia and transient antiphospholipid antibodies were evidenced as factors of thrombophilia. The responsibility of the latter in the onset of the cutaneous lesions is discussed.
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| http://dx.doi.org/10.1067/mjd.2003.340 | DOI Listing |
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