Objective: To evaluate the influence of modest endotoxemia on postoperative antithrombin deficiency and cholestasis.
Summary Background Data: It has not been determined whether endotoxin translocation in small amounts is a physiological phenomenon or whether it is a potential health hazard.
Methods: Blood endotoxin, antithrombin III (ATIII), secretory immunoglobulin A (sIgA), which was selected as a marker of cholestasis, C-reactive protein (CRP), and alpha-1-antitrypsin (AAT) concentrations were measured from the 20 patients undergoing curative gastrectomy for gastric cancer preoperatively and postoperatively. Portal and systemic blood samples were taken for the analysis of endotoxin and interleukin-6 (IL-6) concentrations during surgery in these patients.
Results: Although plasma endotoxin levels showed a significant increase during surgery, we did not find a correlation with ATIII, sIgA, CRP, and IL-6 levels. Systemic blood endotoxin levels during surgery correlated with a postoperative rise of serum AAT levels. Plasma ATIII levels transiently decreased on the first and third postoperative day, and sIgA levels were shown to increase on the seventh postoperative day. There was a weak relationship between the extent of postoperative endotoxemia and a reduction in ATIII concentrations.
Conclusions: The influence of modest endotoxemia on postoperative antithrombin deficiency and cholestasis was limited, and increased translocational endotoxemia during abdominal surgery may be a physiological phenomenon to trigger off an acute-phase protein response.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1422681 | PMC |
| http://dx.doi.org/10.1097/01.sla.0000082711.77096.71 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The association of state policies and opioid analgesic amount dispensed from retail pharmacies.
Drug Alcohol Depend
January 2025
RAND, Boston, MA, United States. Electronic address:
Importance: States have implemented multiple policies likely to influence opioid prescribing; few national general population studies examine those policies' effects on per-capita opioid morphine milligram equivalents (MME) dispensed.
Objective: To examine state policies' effects on opioids per-capita MMEs dispensed at retail pharmacies.
Design: A longitudinal study of associations between MME per capita and implementation of policy interventions at different times across states.
Differential aging trends among Liver Transplant candidates with and without hepatocellular carcinoma.
Liver Transpl
January 2025
Division of Gastroenterology and Hepatology, Department of Medicine, University of California, San Francisco.
Background: Hepatocellular carcinoma (HCC) has become a leading indication for liver transplant (LT), with HCC registrants increasing more than six-fold in the past two decades, accompanied by a significant rise in older candidates. Given this trend and the influence of hepatitis C (HCV) treatments, updated data on aging and changing etiologies in older HCC patients are needed. This study examines age trends, clinical characteristics, and transplant outcomes by comparing older (70+), younger HCC patients, and non-HCC patients.
View Article and Find Full Text PDFNormative CLEFT-Q Data From the General Dutch Population.
J Craniofac Surg
November 2024
Department of Plastic and Reconstructive Surgery and Hand Surgery, Erasmus Medical Center, Rotterdam.
Patient-Reported Outcome Measures (PROMs), such as the CLEFT-Q, have become essential for outcomes in patients with CL/P. Normative values of the CLEFT-Q for non-CL/P peers have not yet been established. This study aims to establish normative values for the CLEFT-Q in the general Dutch population.
View Article and Find Full Text PDFDigital Health Interventions for the Optimization of Postpartum Cardiovascular Health: A Systematic Scoping Review.
Am J Prev Cardiol
March 2025
Leon H. Charney Division of Cardiology, Department of Medicine, NYU Grossman School of Medicine, New York, NY, USA.
Background: Digital health technologies have been proposed as a potential solution to improving maternal cardiovascular (CV) health in the postpartum (PP) period. In this context we performed a systematic scoping review of digital health interventions designed to improve PP CV health.
Methods: We conducted a systematic review of PubMed/MEDLINE, EMBASE, CINAHL, Web of Science and the Cochrane Library.
Evaluating and Improving the Quality of Surgical Operative Notes at the Port Sudan Teaching Hospital.
Cureus
December 2024
General Surgery, Port Sudan Teaching Hospital, Port Sudan, SDN.
Background Thorough and standardized documentation of operative notes is essential for effective communication, patient safety, legal protection, and the continuity of care. However, in many hospitals in Sudan, surgeons often use non-standardized methods, resulting in inconsistent and incomplete records. This study evaluates the quality of operative notes at the Port Sudan Teaching Hospital using the Royal College of Surgeons of England (RCSEng) guidelines, aiming to improve compliance and documentation practices.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!