Dendrites of type II Dogiel neurons (the local receptors) stained with silver nitrate impregnation by Bilschovsky-Gross method, were analyzed with computer morphometry in cat large intestine. The following parameters have been measured: an area of dendritic receptor field, total area of all receptor elements and total length of all receptor branches. Significant individual variability was noted in the values of these parameters: the maximum value exceeded the minimum one by a factor of 41, 29 and 45, respectively. No correlation between these three parameters has been found. It is suggested that the morphological diversity of dendrites found in this study may serve as a basis of the functional variability of type II Dogiel neurons.
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bioRxiv
December 2024
Wu Tsai Neurosciences Institute, Stanford University; Stanford, CA, USA.
Am J Physiol Gastrointest Liver Physiol
March 2024
Department of Biomedical Engineering, University of Connecticut, Storrs, Connecticut, United States.
The enteric nervous system (ENS) functions largely independently of the central nervous system (CNS). Glutamate, the dominant neurotransmitter in the CNS and sensory afferents, is not a primary neurotransmitter in the ENS. Only a fraction (∼2%) of myenteric neurons in the mouse distal colon and rectum (colorectum) are positive for vesicular glutamate transporter type 2 (VGLUT2), the structure and function of which remain undetermined.
View Article and Find Full Text PDFUnlabelled: The enteric nervous system (ENS) functions largely independently of the central nervous system (CNS). Correspondingly, glutamate, the dominant neurotransmitter in the CNS and sensory afferents, is not a primary neurotransmitter in the ENS. Only a fraction (approximately 2%) of myenteric neurons in the mouse distal colon and rectum (colorectum) are positive for vesicular glutamate transporter type 2 (VGLUT2), the structure and function of which remain undetermined.
View Article and Find Full Text PDFChannels (Austin)
December 2023
Department of Medical Genetics, The Second Xiangya Hospital, Central South University, Changsha, China.
The Nav1.9 channel is a voltage-gated sodium channel. It plays a vital role in the generation of pain and the formation of neuronal hyperexcitability after inflammation.
View Article and Find Full Text PDFAdv Exp Med Biol
January 2023
Human Physiology, College of Medicine and Public Health, Flinders University, Adelaide, SA, USA.
Distinguishing and characterising the different classes of neurons that make up a neural circuit has been a long-term goal for many neuroscientists. The enteric nervous system is a large but moderately simple part of the nervous system. Enteric neurons in laboratory animals have been extensively characterised morphologically, electrophysiologically, by projections and immunohistochemically.
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