Two types of Lugaro cells--fusiform and triangular--were found at different levels of granular layer in the sections of cat cerebellar cortex, stained with silver nitrate using Golgi-Kopsch method. Their processes are oriented horizontally, vertically or obliquely to the folium axis, while their axons never leave the limits of cerebellar cortex, therefore these cells should be considered as interneurons. The processes of Lugaro cells have very large spatial expansion, due to which these cells form numerous axosomatic and axodendritic connections with all the neurons and fibers of the cerebellar cortex. Structural and topographic characteristics of Lugaro cells, as well as the peculiarities of their contacts with the other cells of cerebellar cortex, in combination with the data on their neurotransmitter content, indicate that these cells play the role of inhibitory interneurons.
Download full-text PDF |
Source |
---|
Hum Brain Mapp
January 2025
Department of Psychology, Concordia University, Montreal, Quebec, Canada.
The cortex and cerebellum are densely connected through reciprocal input/output projections that form segregated circuits. These circuits are shown to differentially connect anterior lobules of the cerebellum to sensorimotor regions, and lobules Crus I and II to prefrontal regions. This differential connectivity pattern leads to the hypothesis that individual differences in structure should be related, especially for connected regions.
View Article and Find Full Text PDFBackground: Alzheimer's disease (AD) is multifactorial, thus multivariate analyses help untangle its effects. We employed multiple contrast MRI to reveal age‐related brain changes in populations at risk for AD, due to APOE4 carriage. We assessed volume and microstructure changes using diffusion weighted imaging, and quantitative magnetic susceptibility maps (QSM) reflective primarily of cerebral iron metabolism.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Princeton University, Princeton, NJ, USA
Background: Studying brain reserve — the brain’s resilience to age‐related changes or damage — is crucial for understanding protective mechanisms against cognitive decline. The cerebellum may be a key region in brain reserve, but it has been historically understudied. This investigation delves into this critical area within the largest aging multi‐cohort to date.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Wisconsin‐Madison School of Medicine and Public Health, Madison, WI, USA
Background: Sampled iterative local approximation (SILA) is a temporal modeling method previously validated in three cohorts to estimate person‐level amyloid PET onset age and predicted change. This study validates SILA to model longitudinal tau PET trajectories, generate person‐level estimated tau onset age (ETOA), and characterize forward and backward prediction accuracy in the Wisconsin Registry for Alzheimer’s Prevention (WRAP), Wisconsin Alzheimer’s Disease Research Center (WADRC), and the Alzheimer’s Disease Neuroimaging Initiative (ADNI).
Method: N=273 participants (mean(SD) baseline age=70.
Alzheimers Dement
December 2024
Boston University School of Public Health, Boston, MA, USA
Background: The relationship between tau pathology and cognition as a function of age and whether these relationships are consistent across samples is unknown. A growing number of studies now perform positron emission tomography with tau ligands (tau‐PET), making it possible for an improved understanding of the dynamics of tau and cognition in relation to other biomarkers.
Method: We used data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort (ages 55‐90) and The 90+ Study (Table 1) to cover a broad age range.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!