Tianeptine was given to 30 patients aged 39-54 years with essential hypertension and masked, preclinical (n=29) or clinically evident (n=1) depression. This was associated with improvement of clinical psychiatric parameters and data of standardized questionnaire in 29 patients, and with decrease in frequency of hypertensive crises.
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Psychiatry Clin Psychopharmacol
November 2024
Department of Psychiatry, Keimyung University School of Medicine, Daegu, Korea.
Background: The objective is to compare the risk of developing type 2 diabetes (T2D) within a year in patients prescribed various antidepressants (ADs) and those prescribed fluoxetine as a control group.
Methods: This study used standardized data from the Health Insurance Review and Assessment Service claims database (n=1,456,489). Patients aged ≥10 years with no previous use of ADs and no history of diabetes mellitus, regardless of whether they were diagnosed with any depressive disorder, were eligible for this study.
J Pharmacol Sci
December 2024
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi-City, Chiba, 274-8510, Japan.
We investigated the inhibitory effects of 32 antidepressants on [H]N-methylscopolamine ([H]NMS)-specific binding in the mouse cerebral neocortex to determine which antidepressants should be recommended for patients with Alzheimer's disease (AD). Of those tested, nine antidepressants (10 M) exhibited less inhibitory effect on [H]NMS-specific binding (<35%): tianeptine (a tricyclic); trazodone (a serotonin 5-HT blocker); sulpiride (a dopamine D blocker); fluvoxamine (a selective serotonin reuptake inhibitor (RI)); milnacipran, levomilnacipran, venlafaxine, and desvenlafaxine (serotonin and noradrenaline RIs); and bupropion (a noradrenaline and dopamine RI). Therefore, these antidepressants show little anticholinergic effect in the brain and are recommended for use in patients with AD.
View Article and Find Full Text PDFJ Clin Med
August 2024
Unit of Dental Hygiene, Section of Dentistry, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy.
: Several psychological conditions, including stress and depression, can adversely affect oral health; in fact, antidepressants, commonly used to treat depressive disorders, may have conflicting effects on the periodontal status of individuals. The aim of this review was to determine the effects of antidepressants on the periodontium. A literature search was conducted using electronic databases, Pubmed/MEDLINE, Cochrane Library, focusing on the use of antidepressants and their effects on periodontal health in animals or humans.
View Article and Find Full Text PDFCureus
June 2024
Emergency Medicine, Los Robles Regional Medical Center, Thousand Oaks, USA.
The misuse of over-the-counter supplements containing the drug tianeptine poses significant public health concerns, as evidenced by a rise in Poison Control calls and social media discussions regarding its adverse effects. This case report highlights a 67-year-old Caucasian male presenting with symptoms suggestive of tianeptine withdrawal after consuming excessive doses of the supplements daily and their abrupt cessation 12 hours prior to arrival. Despite stable vitals, the patient exhibited anticholinergic toxidrome manifestations, necessitating supportive care and monitoring for acute intoxication.
View Article and Find Full Text PDFJ Opioid Manag
March 2024
Department of Psychiatry and Behavioral Sciences, University of Kansas Health System, Kansas City, Kansas. ORCID: https://orcid.org/0000-0003-4209-591X.
Tianeptine, an antidepressant and full µ-opioid receptor agonist, has increased in popularity and has been used as an over-the-counter supplement over the past decade. Due to its well-documented euphoric effects, there exists elevated risk for potential abuse. Buprenorphine-naloxone has been successfully utilized to treat opioid use disorder (OUD) in patients concurrently using tianeptine, limiting withdrawal symptoms and abstinence.
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