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[Expression of chloride channel in nasal mucosa with allergic rhinitis]. | LitMetric

[Expression of chloride channel in nasal mucosa with allergic rhinitis].

Zhonghua Er Bi Yan Hou Ke Za Zhi

Beijing Institute of Otolaryngology, Department of Otolaryngology Head and Neck Surgery, Tongren Hospital, Capital Medical University, Beijing, 100005, China.

Published: April 2003

Objective: To evaluate the role of chloride channel ClC-3 in perennial allergic rhinitis.

Methods: The nasal mucosa from 19 patients with perennial allergic rhinitis were studied by immunohistochemistric staining and reverse transcriptase polymerase chain reaction (RT-PCR) for the expression of ClC-3.

Results: ClC-3 was positively stained in 17 cases of 19 patients, with a rate of 89.6%. It mainly distributed in cytoplasm of epithelium and submucosal gland. All tissues displayed expected DNA length after PCR. The relative density of ClC-3 in mucosa with allergic rhinitis was 0.685 +/- 0.114 and 0.140 +/- 0.075 in normal.

Conclusion: ClC-3 played an important role in the over-secretion of liquor in allergic rhinitis.

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