Skin thickness is decreasing with age. This loss concerns both dermis and epidermis, cells and extracellular matrix. We could show here that percutaneous application of an L-fucose-containing preparation produced an increase of skin thickness and a densification of collagen bundles. We also could show that 3H-L-fucose penetrates in the dermis, a prerequisite for the above mentioned favorable pharmacological activities. These results, together with the previous favorable activities on the downregulation of matrix-degrading enzymes, free radical scavenging and increased cell proliferation confirm the favorable action of fucose and fucose-rich polysaccharides (FROP-s) on the skin by slowing down its aging.
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Pharmacology of skin aging. Stimulation of glycosaminoglycan biosynthesis by L-fucose and fucose-rich polysaccharides, effect of in vitro aging of fibroblasts.
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April 2004
Laboratoire Universitaire de Recherche en Ophtalmologie, Faculte de Medecine Broussais-Hôtel Dieu, Universite Pierre et Marie Curie (Paris 6), 1, place du Parvis-Notre-Dame, 75181 Paris 4, France.
The effect of L-fucose and fucose-rich polysaccharides (FROP-s [Biomed. Pharmacother., 2003; 57: 187-94]) was investigated, using human skin fibroblast cultures at several passages.
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Biomed Pharmacother
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Laboratoire Universitaire de Recherche en Ophtalmologie, Faculté de Medecine Broussais-Hôtel Dieu, Universite Pierre et Marie Curie, Paris, France.
With increasing age elastic fibres in human skin are progressively lysed and skin elasticity is also decreasing. Still there is an age-dependent increase of elastic fibre surface density, mostly due to an alteration of the fibres. The present experiments were undertaken to explore if L-fucose and fucose-rich polysaccharides (FROP-s) could influence elastin biosynthesis.
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Laboratoire Universitaire de Recherche en Ophtalmologie, Faculte de Medecine Broussais-Hôtel Dieu, Universite Pierre et Marie Curie (Paris 6), 1, place du Parvis-Notre-Dame, 75181 cedex 4, Paris, France.
The action of L-fucose and a fucose-rich oligosaccharide (FROP-3) on skin explant cultures and fibroblast cell cultures, alone or together with three vitamins (A, C, E, often used in topical preparations) was studied, using as criteria collagen accumulation and collagen and non-collagen protein biosynthesis. In order to confirm the results observed, several variants of the chemical procedure were used. Collagen accumulation in cell cultures and (3)H-proline incorporation in proteins and collagen gave comparable results.
View Article and Find Full Text PDFEffect of L-fucose and fucose-rich oligo- and polysaccharides (FROP-s) on skin aging: penetration, skin tissue production and fibrillogenesis.
Biomed Pharmacother
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Laboratoire universitaire de recherche en ophtalmologie, faculté de médecine Broussais-Hôtel Dieu, Universite Pierre-et-Marie-Curie (Paris 6), 1, place du Parvis Notre Dame, 75181 Paris cedex 4, France.
Skin thickness is decreasing with age. This loss concerns both dermis and epidermis, cells and extracellular matrix. We could show here that percutaneous application of an L-fucose-containing preparation produced an increase of skin thickness and a densification of collagen bundles.
View Article and Find Full Text PDFProtection by L-fucose and fucose-rich polysaccharides against ROS-produced cell death in presence of ascorbate.
Biomed Pharmacother
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Laboratoire de Recherche en Ophtalmologie, Faculté de Médecine Broussais-Hôtel Dieu, Université Pierre et Marie Curie (Paris 6), 1, place Parvis Notre Dame, 75181 cedex 4, Paris, France.
It was shown previously, that millimolar concentrations of ascorbate have cytotoxic and anti-proliferative effects (Eur. J. Clin.
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