An experimental model of brain ischemia in pathological kinking and occlusion of carotid artery has been developed on 40 dogs. Each model was documented angiographically, controlled with radionuclides, evaluated morphofunctionally. Basing on the results, surgical indications for correction of brachiocephalic artery lesions are provided.
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SOX9 is a crucial transcriptional regulator of cartilage development and homeostasis. Dysregulation of is associated with a wide spectrum of skeletal disorders, including campomelic dysplasia, acampomelic campomelic dysplasia, and scoliosis. Yet how variants contribute to the spectrum of axial skeletal disorders is not well understood.
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