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A brief history of the cortical thick ascending limb: a systems-biology perspective.
Am J Physiol Renal Physiol
January 2025
Epithelial Systems Biology Laboratory, Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States.
Article Synopsis
- The cortical thick ascending limb (CTAL) of the kidney was first characterized by Maurice Burg in 1973, revealing its role in actively reabsorbing NaCl while having low water permeability, allowing it to produce dilute urine during high water intake.
- In the 1980s, Greger and Schlatter identified the specific membrane transport processes for NaCl, which were further characterized at the molecular level by various researchers in the 1990s using cDNA cloning and advancements in genome sequencing.
- By the 2010s, mathematical models were developed to explore CTAL transport mechanisms, leading to investigations into Burg's 'static head' phenomenon, the adaptation of short CTALs in juxtamedullary nephrons,
Endothelial histone deacetylase 1 activity impairs kidney microvascular NO signaling in rats fed a high-salt diet.
Acta Physiol (Oxf)
September 2024
Section of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
Aim: We aimed to test the hypothesis that a high-salt diet (HS) impairs NO signaling in kidney microvascular endothelial cells through a histone deacetylase 1 (HDAC1)-dependent mechanism.
Methods: Male Sprague Dawley rats were fed normal salt diet (NS; 0.49% NaCl) or HS (4% NaCl) for 2 weeks.
COVID-19 has been a significant public health concern for the last four years; however, little is known about the mechanisms that lead to severe COVID-associated kidney injury. In this multicenter study, we combined quantitative deep urinary proteomics and machine learning to predict severe acute outcomes in hospitalized COVID-19 patients. Using a 10-fold cross-validated random forest algorithm, we identified a set of urinary proteins that demonstrated predictive power for both discovery and validation set with 87% and 79% accuracy, respectively.
View Article and Find Full Text PDFEndothelial Histone Deacetylase 1 Activity Impairs Kidney Microvascular NO Signaling in Rats fed a High Salt Diet.
bioRxiv
March 2023
Section of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL USA.
Aim: We aimed to identify new mechanisms by which a high salt diet (HS) decreases NO production in kidney microvascular endothelial cells. Specifically, we hypothesized HS impairs NO signaling through a histone deacetylase 1 (HDAC1)-dependent mechanism.
Methods: Male Sprague Dawley rats were fed normal salt diet (NS; 0.
Relationship between cortical and medullary thickness and glomerular filtration rate among living kidney donors.
Intern Med J
March 2023
Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia.
Article Synopsis
- The study investigates how the thickness of kidney cortex and medulla relates to the glomerular filtration rate (GFR) in healthy kidney donors.
- Results show a positive relationship between medullary thickness and GFR, while cortical thickness did not show a significant correlation.
- The findings suggest that the number of juxtamedullary nephrons may influence GFR, indicating a specific role for the medulla in kidney function.
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