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Functional Verification of Differentially Expressed Genes Following DENV2 Infection in .
Viruses
January 2025
State Key Laboratory of Pathogen and Biosecurity, Beijing 100071, China.
The dengue virus (DENV) is primarily transmitted by . Investigating genes associated with mosquito susceptibility to DENV2 offers a theoretical foundation for targeted interventions to regulate or block viral replication and transmission within mosquitoes. Based on the transcriptomic analyses of the midgut and salivary glands from infected with DENV2, alongside analyses of Aag2 cell infections, 24 genes potentially related to the regulation of infection with DENV2 were selected.
View Article and Find Full Text PDFGibberellin regulates the synthesis of stone cells in 'Nanguo' pear via the PuMYB91-PuERF023 module.
Physiol Plant
January 2025
Key Laboratory of Fruit Postharvest Biology, Liaoning Province; College of Horticulture, Shenyang Agricultural University, Shenyang, China.
Stone cells are one of the limiting factors affecting pear fruit quality and commodity value. The formation of stone cell is highly correlated with lignin deposition. However, the molecular mechanism of stone cell formation and regulation is still unclear.
View Article and Find Full Text PDFFat mass and obesity-associated protein expression in colorectal cancer and its influence on the biological behaviour of colorectal cancer cells.
Pol J Pathol
January 2025
Clinical Laboratory, Fujian Maternity and Child Health Hospital, Fuzhou, Fujian, China.
Fat mass and obesity-associated protein (FTO) was the earliest discovered m6A RNA demethylase. Previous studies have indicated that m6A modifications significantly influence the development, progression, and prognosis of various cancers. This study aimed to explore the role of FTO overexpression in colorectal cancer development, as well as its biological functions.
View Article and Find Full Text PDFIdentification of a novel heterozygous GPD1 missense variant in a Chinese adult patient with recurrent HTG-AP consuming a high-fat diet and heavy smoking.
BMC Med Genomics
January 2025
Department of Critical Care Medicine, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, No. 321 Zhongshan Road, Nanjing, 210008, Jiangsu Province, China.
Background: Glycerol-3-phosphate dehydrogenase 1 (GPD1) gene defect can cause hypertriglyceridemia (HTG), which usually occurs in infants. The gene defect has rarely been reported in adult HTG patients. In the present study, we described the clinical and functional analyses of a novel GPD1 missense variant in a Chinese adult patient with recurrent hypertriglyceridemia‑related acute pancreatitis (HTG-AP), consuming a high-fat diet and smoking heavily.
View Article and Find Full Text PDFA splice donor in influences keratinocyte immortalization by beta-HPV49.
J Virol
January 2025
Institute for Medical Virology and Epidemiology of Viral Diseases, University of Tuebingen, Tuebingen, Germany.
Human papillomaviruses (HPV) from the genus beta have been implicated in the development of cutaneous squamous cell cancer in and organ transplant patients. In contrast to alpha-high-risk HPV, which cause ano-genital and oropharyngeal cancers, beta-HPV replication is not well understood. The beta-HPV49 transcriptome was analyzed by RNA sequencing using stable keratinocyte cell lines maintaining high levels of extrachromosomally replicating E8- genomes, which can be established due to a lack of the viral E8^E2 repressor protein.
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