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The Associations Between Temperament and Self-Oriented, Other-Oriented, and Dual-Harmful Behaviors in Emerging Adults.
Psychol Belg
December 2024
Faculty of Psychology and Educational Sciences, KU Leuven, Leuven, Belgium.
Self- and other-oriented harmful behaviors are common among emerging adults. Individuals who engage in both forms of behavior, termed dual-harm, experience more adverse outcomes in comparison to individuals who engage in either. This study examines temperamental traits, defined as reactive and regulative temperament, as transdiagnostic factors underlying engagement in self-oriented, other-oriented, and dual-harmful behaviors.
View Article and Find Full Text PDFIntravitreal Administration of Avacincaptad Pegol in a Nonhuman Primate Model of Dry Age-Related Macular Degeneration.
Pharmacol Res Perspect
February 2025
Hamamatsu Pharma Research, Inc., Hamamatsu, Shizuoka, Japan.
The lack of effective treatments for dry age-related macular degeneration (AMD) is in part due to a lack of a preclinical animal model that recapitulates features of the clinical state including macular retinal pigment epithelium (RPE) degeneration, also known as geographic atrophy (GA). A nonhuman primate model of GA was developed and its responsiveness to an approved treatment, avacincaptad pegol (ACP), a complement C5 inhibitor, was evaluated. Intravitreal (ivt) administration of sodium iodate (SI) into one eye of male Macaca fascicularis leads to retinal areas (mm) of hyper- or hypo-autofluorescence.
View Article and Find Full Text PDFForaging and inertia: understanding the developmental dynamics of overt visual attention.
Neurosci Biobehav Rev
December 2024
BabyDevLab, School of Psychology, University of East London, Water Lane, London, E15 4LZ, UK.
During early life, we develop the ability to choose what we focus on and what we ignore, allowing us to regulate perception and action in complex environments. But how does this change influence how we spontaneously allocate attention to real-world objects during free behaviour? Here, in this narrative review, we examine this question by considering the time dynamics of spontaneous overt visual attention, and how these develop through early life. Even in early childhood, visual attention shifts occur both periodically and aperiodically.
View Article and Find Full Text PDFThe molecular mechanism of Xiaoyaosan in treating major depressive disorder: Integrated analysis of DNA methylation and RNA sequencing of the arcuate nucleus in rats.
J Ethnopharmacol
December 2024
School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, PR China; Guangzhou Key Laboratory of Formula-Pattern of Traditional Chinese Medicine, Formula-Pattern Research Center, School of Traditional Chinese Medicine, Jinan University, Guangzhou, 510632, PR China. Electronic address:
Article Synopsis
- Xiaoyaosan, a traditional Chinese herbal remedy, shows potential as an antidepressant, but its mechanisms—particularly in relation to DNA methylation—remain poorly understood, particularly concerning major depressive disorder (MDD).
- The study investigates the antidepressant effects of Xiaoyaosan using a rat model of MDD induced by chronic unpredictable mild stress, comparing results to fluoxetine, and assessing behaviors through various tests while analyzing DNA methylation and gene expression changes through advanced sequencing techniques.
- Findings indicate that Xiaoyaosan not only alleviates depressive behaviors but also induces significant epigenetic changes, with numerous overlapping genes identified that are tied to biological regulatory processes, suggesting its complex role in MDD treatment.
Prevalence and Characteristics of Dyslipidemia in a Hospital in Madagascar.
Cureus
November 2024
Department of Cardiology, Mahavoky Atsimo University Hospital, Mahajanga, MDG.
Introduction Dyslipidemia is a major risk factor for atherosclerosis and is included in the metabolic syndrome. Data on dyslipidemia are still lacking in some parts of Africa. Our objectives were to report the prevalence of dyslipidemia and to describe the lipid profile of patients in a hospital in Madagascar.
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