AI Article Synopsis
- Hairy cell leukemia is a chronic B cell leukemia characterized by unique hairy cells, unusual tissue distribution, and bone marrow fibrosis.
- The authors have been investigating the mechanisms that cause hairy cells to localize in tissues over several years.
- Their research has significantly improved the understanding of these mechanisms and has clarified how bone marrow fibrosis occurs in hairy cell leukemia.
Article Abstract
Hairy cell leukemia is a chronic B cell leukemia with a number of distinctive features including the unusual tissue distribution of the leukemic cells, hairy cells, and the bone marrow fibrosis. We have been working, for a number of years, on the potential mechanisms behind hairy-cell localization in tissues. In this review, it is summarized how our work has shed very important information regarding these mechanisms and led, eventually, to the full elucidation of the process of the bone marrow fibrosis in hairy cell leukemia.
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