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APC/C-mediated ubiquitylation of extranucleosomal histone complexes lacking canonical degrons.
Nat Commun
March 2025
Division of Chemical Biology and Medicinal Chemistry and Center for Integrated Chemical Biology and Drug Discovery, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA.
Non-degradative histone ubiquitylation plays a myriad of well-defined roles in the regulation of gene expression and choreographing DNA damage repair pathways. In contrast, the contributions of degradative histone ubiquitylation on genomic processes has remained elusive. Recently, the APC/C has been shown to ubiquitylate histones to regulate gene expression in pluripotent cells, but the molecular mechanism is unclear.
View Article and Find Full Text PDFEnvironmental justice implications of hydraulic fracturing: A spatio-temporal analysis in texas.
J Environ Manage
March 2025
Keough School of Global Affairs, University of Notre Dame, Notre Dame, IN, USA. Electronic address:
This study contributes to the field of environmental justice by addressing two key questions: (1) To what extent are racial and ethnic composition, socio-demographic characteristics, and housing-related factors associated with the siting of hydraulic fracturing wells in the U.S.? and (2) How have these associations evolved over time, and have demographic changes contributed to increased environmental justice concerns? Using a panel dataset from FracFocus and the American Community Survey at the census-tract level between 2011 and 2023, the findings reveal that hydraulic fracturing wells are disproportionately located near census tracts with higher percentages of Black and Hispanic populations, indicating environmental injustice towards racial minorities.
View Article and Find Full Text PDFBlood Pressure and Heart Rate Response to Orthostasis in Somali Americans.
J Racial Ethn Health Disparities
March 2025
Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, 55905, USA.
Purpose: Cardiovascular health disparities are present in African Americans, but it remains unknown whether this phenomenon affects Somali Americans. Study of Somali Americans is warranted due to distinct genetic and cultural differences from African Americans of western African ancestry. Orthostatic hemodynamic responses have implications for cardiovascular risk, especially among African American females.
View Article and Find Full Text PDFExploring the shared genetic landscape of diabetes and cardiovascular disease: findings and future implications.
Diabetologia
March 2025
Department of Internal Medicine, Seoul National University College of Medicine and Seoul National University Hospital, Seoul, Korea.
Diabetes is a rapidly growing global health concern projected to affect one in eight adults by 2045, which translates to roughly 783 million people. The profound metabolic alterations often present in dysglycaemia significantly increase the risk of cardiovascular complications. While genetic susceptibility plays a crucial role in diabetes and its vascular complications, identifying genes and molecular mechanisms that influence both diseases simultaneously has proven challenging.
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