Objective: To develop a new photochemical method of experimental retinal vein occlusion and investigate the morphologic and histologic changes in the retina.
Methods: After intravenous injection of rose Bengal, the vessels next to the disc of miniature pigs in the experiment group (n = 15) were exposed to an endo-illuminator for 15 minutes. As a control group, the vessels next to the disc of each pig were exposed to the endo-illuminator without rose Bengal injection. After complete vascular occlusion, the eyes were observed at following times: one hour, and 1, 3, 7, 14, 21, and 28 days. After the 28th day, the eyes were enucleated and prepared for light and electron microscope examination.
Results: Histopathologic features were consistent with changes of retinal vein occlusion and formation of retinal vein thrombi was reliable.
Conclusions: Photodynamic method combined with endo-illuminator was a simple, reliable and definitive experimental technique to produce retinal vein occlusion.
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